| Tag | Content |
|---|
| CPLM ID | CPLM-020893 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 22 member 17 |
Protein Synonyms/Alias | 24p3 receptor; 24p3R; Brain-type organic cation transporter; Lipocalin-2 receptor |
Gene Name | Slc22a17 |
Gene Synonyms/Alias | Boct |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 362 | LLPETKRKLLPEVLR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
Sequence Annotation | |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Ion transport; Iron; Iron transport; Membrane; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Transport; Vacuole. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 401 AA |
Protein Sequence | MPSARFGRRG IVLLTLGLVG PCGVGGAAAG SSTGIMALRF LLGFLLAGVD LGVYLMRLEL 60
CDPTQRLRVA LAGELVGVGG HFLFLGLALV SKDWRFLQRM ITAPCILFLF YGWPGLFLES 120
ARWLIVKRQI EEAQSVLRIL AERNRPHGQM LGEEAQEALQ ELENTCPLPA TSTFSFASLL 180
NYRNIWKNLL ILGFTNFIAH AIRHCYQPVG GGGSPSDFYL CSLLASGTAA LACVFLGVTV 240
DRFGRRGILL LSMTLTGIAS LVLLGLWDYL NDAAITTFSV LGLFSSQASA ILSTLLASEV 300
IPTTVRGRGL GLIMALGALG GLSCPAQRLH MGHGAFLQHV VLAACALLCI LSIMLLPETK 360
RKLLPEVLRD GELCRRPSLL RQPPPNRCDH VPLLATPNPA L 401 |
Gene Ontology | GO:0031301; C:integral to organelle membrane; ISS:UniProtKB. GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell. GO:0004888; F:transmembrane signaling receptor activity; IMP:UniProtKB. GO:0022857; F:transmembrane transporter activity; IEA:InterPro. GO:0006811; P:ion transport; IEA:UniProtKB-KW. GO:0015891; P:siderophore transport; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |