| Tag | Content |
|---|
| CPLM ID | CPLM-010233 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Succinate semialdehyde dehydrogenase [NAD(P)+] Sad |
Protein Synonyms/Alias | SSADH; SSDH |
Gene Name | sad |
Gene Synonyms/Alias | yneI; b1525; JW5247 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 325 | ELHHQVEKTLAQGAR | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Catalyzes the NAD(+)-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources. |
Sequence Annotation | NP_BIND 136 137 NAD or NADP (By similarity).
NP_BIND 160 163 NAD or NADP (By similarity).
NP_BIND 212 217 NAD or NADP (By similarity).
ACT_SITE 234 234 Proton acceptor (By similarity).
ACT_SITE 268 268 Nucleophile (By similarity).
BINDING 235 235 NAD or NADP; via carbonyl oxygen (By
BINDING 365 365 NAD or NADP (By similarity). |
Keyword | Complete proteome; NADP; Oxidoreductase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 462 AA |
Protein Sequence | MTITPATHAI SINPATGEQL SVLPWAGADD IENALQLAAA GFRDWRETNI DYRAEKLRDI 60
GKALRARSEE MAQMITREMG KPINQARAEV AKSANLCDWY AEHGPAMLKA EPTLVENQQA 120
VIEYRPLGTI LAIMPWNFPL WQVMRGAVPI ILAGNGYLLK HAPNVMGCAQ LIAQVFKDAG 180
IPQGVYGWLN ADNDGVSQMI KDSRIAAVTV TGSVRAGAAI GAQAGAALKK CVLELGGSDP 240
FIVLNDADLE LAVKAAVAGR YQNTGQVCAA AKRFIIEEGI ASAFTERFVA AAAALKMGDP 300
RDEENALGPM ARFDLRDELH HQVEKTLAQG ARLLLGGEKM AGAGNYYPPT VLANVTPEMT 360
AFREEMFGPV AAITIAKDAE HALELANDSE FGLSATIFTT DETQARQMAA RLECGGVFIN 420
GYCASDARVA FGGVKKSGFG RELSHFGLHE FCNIQTVWKD RI 462 |
Gene Ontology | GO:0004777; F:succinate-semialdehyde dehydrogenase (NAD+) activity; IDA:UniProtKB. GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IDA:EcoCyc. GO:0006527; P:arginine catabolic process; IMP:EcoCyc. GO:0009450; P:gamma-aminobutyric acid catabolic process; IMP:EcoliWiki. GO:0009447; P:putrescine catabolic process; IMP:EcoCyc. |
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Pfam | |
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PROSITE | |
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