CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022014
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable Xaa-Pro aminopeptidase 3 
Protein Synonyms/Alias
 X-Pro aminopeptidase 3; Aminopeptidase P3; APP3 
Gene Name
 XPNPEP3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
247IQRLRLIKSPAEIERubiquitination[1]
317SNTLHYVKNNQLIKDubiquitination[2]
323VKNNQLIKDGEMVLLubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 METAL 331 331 Manganese 2 (By similarity).
 METAL 342 342 Manganese 1 (By similarity).
 METAL 342 342 Manganese 2 (By similarity).
 METAL 424 424 Manganese 1 (By similarity).
 METAL 451 451 Manganese 1 (By similarity).
 METAL 475 475 Manganese 1 (By similarity).
 METAL 475 475 Manganese 2 (By similarity).  
Keyword
 Alternative splicing; Aminopeptidase; Ciliopathy; Complete proteome; Disease mutation; Hydrolase; Manganese; Metal-binding; Metalloprotease; Mitochondrion; Nephronophthisis; Polymorphism; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MPWLLSAPKL VPAVANVRGL SGCMLCSQRR YSLQPVPERR IPNRYLGQPS PFTHPHLLRP 60
GEVTPGLSQV EYALRRHKLM SLIQKEAQGQ SGTDQTVVVL SNPTYYMSND IPYTFHQDNN 120
FLYLCGFQEP DSILVLQSLP GKQLPSHKAI LFVPRRDPSR ELWDGPRSGT DGAIALTGVD 180
EAYTLEEFQH LLPKMKAETN MVWYDWMRPS HAQLHSDYMQ PLTEAKAKSK NKVRGVQQLI 240
QRLRLIKSPA EIERMQIAGK LTSQAFIETM FTSKAPVEEA FLYAKFEFEC RARGADILAY 300
PPVVAGGNRS NTLHYVKNNQ LIKDGEMVLL DGGCESSCYV SDITRTWPVN GRFTAPQAEL 360
YEAVLEIQRD CLALCFPGTS LENIYSMMLT LIGQKLKDLG IMKNIKENNA FKAARKYCPH 420
HVGHYLGMDV HDTPDMPRSL PLQPGMVITI EPGIYIPEDD KDAPEKFRGL GVRIEDDVVV 480
TQDSPLILSA DCPKEMNDIE QICSQAS 507 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004177; F:aminopeptidase activity; IMP:MGI.
 GO:0030145; F:manganese ion binding; IEA:InterPro.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0009987; P:cellular process; IEA:InterPro.
 GO:0003094; P:glomerular filtration; IMP:MGI.
 GO:0016485; P:protein processing; IMP:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR007865; Aminopep_P_N.
 IPR000994; Pept_M24_structural-domain. 
Pfam
 PF05195; AMP_N
 PF00557; Peptidase_M24 
SMART
 SM01011; AMP_N 
PROSITE
  
PRINTS