CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004897
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 33 
Protein Synonyms/Alias
 Protein SLP1; Vacuolar morphogenesis protein 5 
Gene Name
 VPS33 
Gene Synonyms/Alias
 SLP1; VAM5; YLR396C; L8084.15 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
346PQLNKLAKELQTQYDubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Essential for vacuolar biogenesis, maturation and function. Involved in the sorting of vacuolar proteins from the Golgi apparatus and their targeting to the vacuole. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion. 
Sequence Annotation
 MOD_RES 626 626 Phosphoserine.  
Keyword
 Complete proteome; Phosphoprotein; Protein transport; Reference proteome; Transport; Vacuole. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 691 AA 
Protein Sequence
MNRFWNTKKF SLTNADGLCA TLNEISQNDE VLVVQPSVLP VLNSLLTFQD LTQSTPVRKI 60
TLLDDQLSDD LPSALGSVPQ MDLIFLIDVR TSLRLPPQLL DAAQKHNLSS LHIIYCRWKP 120
SFQNTLEDTE QWQKDGFDLN SKKTHFPNVI ESQLKELSNE YTLYPWDLLP FPQIDENVLL 180
THSLYNMENV NMYYPNLRSL QSATESILVD DMVNSLQSLI FETNSIITNV VSIGNLSKRC 240
SHLLKKRIDE HQTENDLFIK GTLYGERTNC GLEMDLIILE RNTDPITPLL TQLTYAGILD 300
DLYEFNSGIK IKEKDMNFNY KEDKIWNDLK FLNFGSIGPQ LNKLAKELQT QYDTRHKAES 360
VHEIKEFVDS LGSLQQRQAF LKNHTTLSSD VLKVVETEEY GSFNKILELE LEILMGNTLN 420
NDIEDIILEL QYQYEVDQKK ILRLICLLSL CKNSLREKDY EYLRTFMIDS WGIEKCFQLE 480
SLAELGFFTS KTGKTDLHIT TSKSTRLQKE YRYISQWFNT VPIEDEHAAD KITNENDDFS 540
EATFAYSGVV PLTMRLVQML YDRSILFHNY SSQQPFILSR EPRVSQTEDL IEQLYGDSHA 600
IEESIWVPGT ITKKINASIK SNNRRSIDGS NGTFHAAEDI ALVVFLGGVT MGEIAIMKHL 660
QKILGKKGIN KRFIIIADGL INGTRIMNSI S 691 
Gene Ontology
 GO:0033263; C:CORVET complex; IDA:SGD.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.
 GO:0030897; C:HOPS complex; IPI:SGD.
 GO:0005524; F:ATP binding; IDA:SGD.
 GO:0006897; P:endocytosis; IMP:SGD.
 GO:0006896; P:Golgi to vacuole transport; IMP:SGD.
 GO:0034727; P:piecemeal microautophagy of nucleus; IMP:SGD.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD.
 GO:0035542; P:regulation of SNARE complex assembly; IDA:SGD.
 GO:0032889; P:regulation of vacuole fusion, non-autophagic; IDA:SGD.
 GO:0042144; P:vacuole fusion, non-autophagic; IMP:SGD.
 GO:0048278; P:vesicle docking; IGI:SGD.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
 GO:0051469; P:vesicle fusion with vacuole; IGI:SGD. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like.
 IPR027121; VPS33. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS