CPLM-002612

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-002612

UniProt Accession

MDR1_HUMAN; P08183; A8K294; Q12755; Q14812

Genbank Protein ID

M14758; M29447; M29424; M29425; M29426; M29427; M29428; M29429; M29430; M29431; M29432; M29433; M29434; M29435; M29436; M29437; M29438; M29439; M29440; M29441; M29442; M29443; M29444; M29445; M29446; AF016535; AY910577; AK290159; AC002457; AC005068; M37724; M37725; X58723

Genbank Nucleotide ID

AAA59575.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAA59576.1; AAB69423.1; AAW82430.1; BAF82848.1; AAM49149.1; AAA88047.1; AAA88048.1; CAA41558.1

Protein Name

Multidrug resistance protein 1

Protein Synonyms/Alias

ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243

Gene Name

ABCB1

Gene Synonyms/Alias

MDR1; PGY1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
181	RLTDDVSKINEGIGD	ubiquitination	[1]
242	ILSSFTDKELLAYAK	ubiquitination	[1]
249	KELLAYAKAGAVAEE	ubiquitination	[1]
271	VIAFGGQKKELERYN	ubiquitination	[1]
279	KELERYNKNLEEAKR	ubiquitination	[1, 2]
367	GAAYEIFKIIDNKPS	ubiquitination	[1, 2]
372	IFKIIDNKPSIDSYS	ubiquitination	[1]
380	PSIDSYSKSGHKPDN	ubiquitination	[1]
389	GHKPDNIKGNLEFRN	ubiquitination	[1]
515	NAYDFIMKLPHKFDT	ubiquitination	[1, 2]
519	FIMKLPHKFDTLVGE	ubiquitination	[1, 2]
575	VVQVALDKARKGRTT	ubiquitination	[1]
609	DDGVIVEKGNHDELM	ubiquitination	[1]
617	GNHDELMKEKGIYFK	ubiquitination	[1]
645	ENAADESKSEIDALE	ubiquitination	[1]
808	VSWFDDPKNTTGALT	ubiquitination	[1]
826	ANDAAQVKGAIGSRL	ubiquitination	[1]
915	VSLTQEQKFEHMYAQ	ubiquitination	[1, 2]
1093	FYDPLAGKVLLDGKE	ubiquitination	[1, 2]
1164	FIESLPNKYSTKVGD	ubiquitination	[2]
1212	ALDTESEKVVQEALD	ubiquitination	[1]
1220	VVQEALDKAREGRTC	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]

Functional Description

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Sequence Annotation

DOMAIN 51 357 ABC transmembrane type-1 1.
DOMAIN 392 628 ABC transporter 1.
DOMAIN 711 1000 ABC transmembrane type-1 2.
DOMAIN 1035 1273 ABC transporter 2.
NP_BIND 427 434 ATP 1 (By similarity).
NP_BIND 1070 1077 ATP 2 (By similarity).
MOD_RES 660 660 Phosphoserine (By similarity).
CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
CARBOHYD 94 94 N-linked (GlcNAc...) (Potential).
CARBOHYD 99 99 N-linked (GlcNAc...) (Potential).

Keyword

ATP-binding; Cell membrane; Complete proteome; Glycoprotein; Hydrolase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1280 AA

Protein Sequence

MDLEGDRNGG AKKKNFFKLN NKSEKDKKEK KPTVSVFSMF RYSNWLDKLY MVVGTLAAII 60
HGAGLPLMML VFGEMTDIFA NAGNLEDLMS NITNRSDIND TGFFMNLEED MTRYAYYYSG 120
IGAGVLVAAY IQVSFWCLAA GRQIHKIRKQ FFHAIMRQEI GWFDVHDVGE LNTRLTDDVS 180
KINEGIGDKI GMFFQSMATF FTGFIVGFTR GWKLTLVILA ISPVLGLSAA VWAKILSSFT 240
DKELLAYAKA GAVAEEVLAA IRTVIAFGGQ KKELERYNKN LEEAKRIGIK KAITANISIG 300
AAFLLIYASY ALAFWYGTTL VLSGEYSIGQ VLTVFFSVLI GAFSVGQASP SIEAFANARG 360
AAYEIFKIID NKPSIDSYSK SGHKPDNIKG NLEFRNVHFS YPSRKEVKIL KGLNLKVQSG 420
QTVALVGNSG CGKSTTVQLM QRLYDPTEGM VSVDGQDIRT INVRFLREII GVVSQEPVLF 480
ATTIAENIRY GRENVTMDEI EKAVKEANAY DFIMKLPHKF DTLVGERGAQ LSGGQKQRIA 540
IARALVRNPK ILLLDEATSA LDTESEAVVQ VALDKARKGR TTIVIAHRLS TVRNADVIAG 600
FDDGVIVEKG NHDELMKEKG IYFKLVTMQT AGNEVELENA ADESKSEIDA LEMSSNDSRS 660
SLIRKRSTRR SVRGSQAQDR KLSTKEALDE SIPPVSFWRI MKLNLTEWPY FVVGVFCAII 720
NGGLQPAFAI IFSKIIGVFT RIDDPETKRQ NSNLFSLLFL ALGIISFITF FLQGFTFGKA 780
GEILTKRLRY MVFRSMLRQD VSWFDDPKNT TGALTTRLAN DAAQVKGAIG SRLAVITQNI 840
ANLGTGIIIS FIYGWQLTLL LLAIVPIIAI AGVVEMKMLS GQALKDKKEL EGSGKIATEA 900
IENFRTVVSL TQEQKFEHMY AQSLQVPYRN SLRKAHIFGI TFSFTQAMMY FSYAGCFRFG 960
AYLVAHKLMS FEDVLLVFSA VVFGAMAVGQ VSSFAPDYAK AKISAAHIIM IIEKTPLIDS 1020
YSTEGLMPNT LEGNVTFGEV VFNYPTRPDI PVLQGLSLEV KKGQTLALVG SSGCGKSTVV 1080
QLLERFYDPL AGKVLLDGKE IKRLNVQWLR AHLGIVSQEP ILFDCSIAEN IAYGDNSRVV 1140
SQEEIVRAAK EANIHAFIES LPNKYSTKVG DKGTQLSGGQ KQRIAIARAL VRQPHILLLD 1200
EATSALDTES EKVVQEALDK AREGRTCIVI AHRLSTIQNA DLIVVFQNGR VKEHGTHQQL 1260
LAQKGIYFSM VSVQAGTKRQ 1280

Gene Ontology

GO:0016324; C:apical plasma membrane; IBA:RefGenome.
GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0000139; C:Golgi membrane; IBA:RefGenome.
GO:0016021; C:integral to membrane; IBA:RefGenome.
GO:0046581; C:intercellular canaliculus; IBA:RefGenome.
GO:0005524; F:ATP binding; TAS:ProtInc.
GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:RefGenome.
GO:0008559; F:xenobiotic-transporting ATPase activity; IEA:EC.
GO:0006855; P:drug transmembrane transport; TAS:Reactome.
GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:DFLAT.
GO:0072089; P:stem cell proliferation; IMP:DFLAT.

Interpro

IPR003593; AAA+_ATPase.
IPR003439; ABC_transporter-like.
IPR017871; ABC_transporter_CS.
IPR017940; ABC_transporter_type1.
IPR001140; ABC_transptr_TM_dom.
IPR011527; ABC_transptrTM_dom_typ1.
IPR027417; P-loop_NTPase.

Pfam

PF00664; ABC_membrane
PF00005; ABC_tran

SMART

SM00382; AAA

PROSITE

PS50929; ABC_TM1F
PS00211; ABC_TRANSPORTER_1
PS50893; ABC_TRANSPORTER_2

PRINTS