UniProt Accession

 ZYX_HUMAN; Q15942; A4D2G6; Q6I9S4 

Genbank Protein ID

 X94991; X95735; CR457431; AC092214; CH236959; BC008743; BC009360; BC010031 

Genbank Nucleotide ID

 CAA64447.1; CAA65050.1; CAG33712.1; AAS07459.1; EAL23788.1; AAH08743.1; AAH09360.1; AAH10031.1 

Protein Name

 Zyxin 

Protein Synonyms/Alias

 Zyxin-2 

Gene Name

 ZYX 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	PAFYAPQKKFGPVVA	acetylation	[1]
265	SSPAPAPKFSPVTPK	ubiquitination	[2, 3, 4]
272	KFSPVTPKFTPVASK	ubiquitination	[3]
279	KFTPVASKFSPGAPG	acetylation	[1]
279	KFTPVASKFSPGAPG	ubiquitination	[3]
295	SGSQPNQKLGHPEAL	ubiquitination	[3]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). 

Sequence Annotation

 DOMAIN 384 443 LIM zinc-binding 1.
 DOMAIN 444 503 LIM zinc-binding 2.
 DOMAIN 504 570 LIM zinc-binding 3.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 143 143 Phosphoserine (By similarity).
 MOD_RES 159 159 Phosphothreonine (By similarity).
 MOD_RES 169 169 Phosphoserine.
 MOD_RES 179 179 Phosphothreonine.
 MOD_RES 259 259 Phosphoserine.
 MOD_RES 267 267 Phosphoserine.
 MOD_RES 270 270 Phosphothreonine.
 MOD_RES 274 274 Phosphothreonine.
 MOD_RES 279 279 N6-acetyllysine.
 MOD_RES 281 281 Phosphoserine.
 MOD_RES 288 288 Phosphoserine.
 MOD_RES 308 308 Phosphoserine.
 MOD_RES 344 344 Phosphoserine.  

Keyword

 Acetylation; Cell adhesion; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Host-virus interaction; LIM domain; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 572 AA 

Protein Sequence

Gene Ontology

 GO:0005913; C:cell-cell adherens junction; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005925; C:focal adhesion; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0001725; C:stress fiber; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM 

SMART

 SM00132; LIM 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 

PRINTS