CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020169
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 1 
Protein Synonyms/Alias
 LANO adapter protein; LAP and no PDZ protein 
Gene Name
 LRRC1 
Gene Synonyms/Alias
 LANO 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
60EQFFQLVKLRKLGLSubiquitination[1, 2, 3]
63FQLVKLRKLGLSDNEubiquitination[2]
105PESISFCKALQVADFubiquitination[2]
381PLSLTALKLKALWLSubiquitination[1, 2, 3]
465IRFVEDEKDEEDNETubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
 REPEAT 11 34 LRR 1.
 REPEAT 35 58 LRR 2.
 REPEAT 60 81 LRR 3.
 REPEAT 83 105 LRR 4.
 REPEAT 107 126 LRR 5.
 REPEAT 127 149 LRR 6.
 REPEAT 150 172 LRR 7.
 REPEAT 173 196 LRR 8.
 REPEAT 198 218 LRR 9.
 REPEAT 219 242 LRR 10.
 REPEAT 244 264 LRR 11.
 REPEAT 265 288 LRR 12.
 REPEAT 290 310 LRR 13.
 REPEAT 311 334 LRR 14.
 REPEAT 336 356 LRR 15.
 REPEAT 357 380 LRR 16.
 REPEAT 382 405 LRR 17.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Leucine-rich repeat; Membrane; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 524 AA 
Protein Sequence
MFHCIPLWRC NRHVESIDKR HCSLVYVPEE IYRYARSLEE LLLDANQLRE LPEQFFQLVK 60
LRKLGLSDNE IQRLPPEIAN FMQLVELDVS RNEIPEIPES ISFCKALQVA DFSGNPLTRL 120
PESFPELQNL TCLSVNDISL QSLPENIGNL YNLASLELRE NLLTYLPDSL TQLRRLEELD 180
LGNNEIYNLP ESIGALLHLK DLWLDGNQLS ELPQEIGNLK NLLCLDVSEN RLERLPEEIS 240
GLTSLTDLVI SQNLLETIPD GIGKLKKLSI LKVDQNRLTQ LPEAVGECES LTELVLTENQ 300
LLTLPKSIGK LKKLSNLNAD RNKLVSLPKE IGGCCSLTVF CVRDNRLTRI PAEVSQATEL 360
HVLDVAGNRL LHLPLSLTAL KLKALWLSDN QSQPLLTFQT DTDYTTGEKI LTCVLLPQLP 420
SEPTCQENLP RCGALENLVN DVSDEAWNER AVNRVSAIRF VEDEKDEEDN ETRTLLRRAT 480
PHPGELKHMK KTVENLRNDM NAAKGLDSNK NEVNHAIDRV TTSV 524 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4. 
Pfam
 PF00560; LRR_1
 PF12799; LRR_4 
SMART
  
PROSITE
 PS51450; LRR 
PRINTS