UniProt Accession

 FANCF_HUMAN; Q9NPI8; Q52LM0 

Genbank Protein ID

 AF181995; AF181994; AK023153; AY928335; BC047028; BC093867; BC101807 

Genbank Nucleotide ID

 AAF26298.1; AAF26297.1; BAB14433.1; AAX09677.1; AAH47028.1; AAH93867.1; AAI01808.1 

Protein Name

 Fanconi anemia group F protein 

Protein Synonyms/Alias

 Protein FACF 

Gene Name

 FANCF 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
164	LQEDSLMKTQAELLL	ubiquitination	[1, 2]
179	ERLQEVGKAEAERPA	ubiquitination	[2]
322	CQAPPPLKDKVLTAL	ubiquitination	[2]
324	APPPLKDKVLTALET	ubiquitination	[2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; DNA damage; DNA repair; Fanconi anemia; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 374 AA 

Protein Sequence

Gene Ontology

 GO:0043240; C:Fanconi anaemia nuclear complex; IDA:UniProtKB.
 GO:0006281; P:DNA repair; TAS:Reactome. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS