UniProt Accession

 CRBB3_HUMAN; P26998; Q3B7S9; Q3T1B7; Q6ISK6; Q92965; Q9UH09 

Genbank Protein ID

 CR456427; Z99916; BC069479; BC102021; BC102022; BC107482; U71216; X15144; X15145; X15146 

Genbank Nucleotide ID

 CAG30313.1; CAB17042.1; AAH69479.2; AAI02022.1; AAI02023.1; AAI07483.1; AAC50972.1; CAA33242.2; CAA33242.2; CAA33242.2 

Protein Name

 Beta-crystallin B3 

Protein Synonyms/Alias

 Beta-B3 crystallin; Beta-crystallin B3, N-terminally processed 

Gene Name

 CRYBB3 

Gene Synonyms/Alias

 CRYB3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
128	NPAFSGRKMEIVDDD	acetylation	[1]
128	NPAFSGRKMEIVDDD	methylation	[1, 2]

Reference

 [1] Shotgun identification of protein modifications from protein complexes and lens tissue.
 MacCoss MJ, McDonald WH, Saraf A, Sadygov R, Clark JM, Tasto JJ, Gould KL, Wolters D, Washburn M, Weiss A, Clark JI, Yates JR 3rd.
 Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7900-5. [PMID: 12060738]
 [2] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681] 

Functional Description

 Crystallins are the dominant structural components of the vertebrate eye lens. 

Sequence Annotation

 DOMAIN 24 63 Beta/gamma crystallin 'Greek key' 1.
 DOMAIN 64 108 Beta/gamma crystallin 'Greek key' 2.
 DOMAIN 114 155 Beta/gamma crystallin 'Greek key' 3.
 DOMAIN 156 198 Beta/gamma crystallin 'Greek key' 4.
 REGION 1 23 N-terminal arm.
 REGION 109 113 Connecting peptide.
 REGION 200 211 C-terminal arm.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 2 2 N-acetylalanine; in Beta-crystallin B3,  

Keyword

 3D-structure; Acetylation; Cataract; Complete proteome; Disease mutation; Eye lens protein; Oxidation; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 211 AA 

Protein Sequence

Gene Ontology

 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; TAS:ProtInc. 

Interpro

 IPR001064; Beta/gamma_crystallin.
 IPR011024; G_crystallin-rel. 

Pfam

 PF00030; Crystall 

SMART

 SM00247; XTALbg 

PROSITE

 PS50915; CRYSTALLIN_BETA_GAMMA 

PRINTS

 PR01367; BGCRYSTALLIN.