| Tag | Content |
|---|
| CPLM ID | CPLM-016184 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein prune homolog |
Protein Synonyms/Alias | hPrune; Drosophila-related expressed sequence 17; DRES-17; DRES17; HTcD37 |
Gene Name | PRUNE |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 200 | KDSKYVEKLEALFPD | ubiquitination | [1] | | 210 | ALFPDLPKRNDIFDS | ubiquitination | [1] | | 220 | DIFDSLQKAKFDVSG | ubiquitination | [1] | | 222 | FDSLQKAKFDVSGLT | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. |
Sequence Annotation | REGION 393 420 Essential for homodimerization.
MOTIF 106 108 DHH motif.
METAL 28 28 Manganese 1 (By similarity).
METAL 30 30 Manganese 2 (By similarity).
METAL 106 106 Manganese 1 (By similarity).
METAL 106 106 Manganese 2 (By similarity).
METAL 179 179 Manganese 2 (By similarity). |
Keyword | Alternative splicing; Cell junction; Complete proteome; Cytoplasm; Hydrolase; Manganese; Metal-binding; Nucleus; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 453 AA |
Protein Sequence | MEDYLQGCRA ALQESRPLHV VLGNEACDLD STVSALALAF YLAKTTEAEE VFVPVLNIKR 60
SELPLRGDIV FFLQKVHIPE SILIFRDEID LHALYQAGQL TLILVDHHIL SKSDTALEEA 120
VAEVLDHRPI EPKHCPPCHV SVELVGSCAT LVTERILQGA PEILDRQTAA LLHGTIILDC 180
VNMDLKIGKA TPKDSKYVEK LEALFPDLPK RNDIFDSLQK AKFDVSGLTT EQMLRKDQKT 240
IYRQGVKVAI SAIYMDLEAF LQRSNLLADL HAFCQAHSYD VLVAMTIFFN THNEPVRQLA 300
IFCPHVALQT TICEVLERSH SPPLKLTPAS STHPNLHAYL QGNTQVSRKK LLPLLQEALS 360
AYFDSMKIPS GQPETADVSR EQVDKELDRA SNSLISGLSQ DEEDPPLPPT PMNSLVDECP 420
LDQGLPKLSA EAVFEKCSQI SLSQSTTASL SKK 453 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |