CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029837
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho guanine nucleotide exchange factor 9 
Protein Synonyms/Alias
 cDNA FLJ59516, highly similar to Homo sapiens Cdc42 guanine nucleotide exchange factor (GEF) 9 (ARHGEF9), mRNA 
Gene Name
 ARHGEF9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
110DICEGYLKQCRKRRDmethylation[1]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; SH3 domain. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 495 AA 
Protein Sequence
MANRELAFKA GDVIKVLDAS NKDWWWGQID DEEGWFPASF VRLWVNQEDE VEEGPSDVQN 60
GHLDPNSDCL CLGRPLQNRD QMRANVINEI MSTERHYIKH LKDICEGYLK QCRKRRDMFS 120
DEQLKVIFGN IEDIYRFQMG FVRDLEKQYN NDDPHLSEIG PCFLEHQDGF WIYSEYCNNH 180
LDACMELSKL MKDSRYQHFF EACRLLQQMI DIAIDGFLLT PVQKICKYPL QLAELLKYTA 240
QDHSDYRYVA AALAVMRNVT QQINERKRRL ENIDKIAQWQ ASVLDWEGED ILDRSSELIY 300
TGEMAWIYQP YGRNQQRVFF LFDHQMVLCK KDLIRRDILY YKGRIDMDKY EVVDIEDGRD 360
DDFNVSMKNA FKLHNKETEE IHLFFAKKLE EKIRWLRAFR EERKMVQEDE KIGFEISENQ 420
KRQAAMTVRK VPKQKGVNSA RSVPPSYPPP QDPLNHGQYL VPDGIAQSQV FEFTEPKRSQ 480
SPFWQNFSRL TPFKK 495 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR001452; SH3_domain. 
Pfam
 PF00169; PH
 PF00621; RhoGEF
 PF00018; SH3_1 
SMART
 SM00233; PH
 SM00325; RhoGEF
 SM00326; SH3 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS50002; SH3 
PRINTS