UniProt Accession

 URIC_RAT; P09118 

Genbank Protein ID

 J03959; X13098; M24396; X07497; M63593; M63583; M63586; M63587; M63588; M63590; M63591; M63592; BC088112 

Genbank Nucleotide ID

 AAA42318.1; CAA31490.1; AAA42317.1; CAA30378.1; AAA61699.1; AAA61699.1; AAA61699.1; AAA61699.1; AAA61699.1; AAA61699.1; AAA61699.1; AAA61699.1; AAH88112.1 

Protein Name

 Uricase 

Protein Synonyms/Alias

 Urate oxidase 

Gene Name

 Uox 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
27	GYGKDMVKVLHIQRD	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin. 

Sequence Annotation

 REGION 68 69 Substrate binding (By similarity).
 REGION 234 235 Substrate binding (By similarity).
 MOTIF 301 303 Microbody targeting signal (Potential).
 ACT_SITE 187 187 Charge relay system (By similarity).
 ACT_SITE 235 235 Charge relay system (By similarity).
 BINDING 187 187 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 36 36 N6-acetyllysine (By similarity).
 MOD_RES 39 39 Phosphoserine (By similarity).
 MOD_RES 55 55 N6-acetyllysine (By similarity).
 MOD_RES 118 118 N6-acetyllysine (By similarity).
 MOD_RES 122 122 N6-acetyllysine (By similarity).
 MOD_RES 164 164 N6-acetyllysine (By similarity).
 MOD_RES 185 185 N6-acetyllysine (By similarity).
 MOD_RES 220 220 N6-acetyllysine (By similarity).
 MOD_RES 231 231 Phosphoserine (By similarity).
 MOD_RES 277 277 N6-acetyllysine (By similarity).
 MOD_RES 290 290 N6-acetyllysine (By similarity).
 MOD_RES 301 301 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Oxidoreductase; Peroxisome; Phosphoprotein; Purine metabolism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 303 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005782; C:peroxisomal matrix; TAS:RGD.
 GO:0004846; F:urate oxidase activity; TAS:RGD.
 GO:0006145; P:purine nucleobase catabolic process; TAS:RGD.
 GO:0019628; P:urate catabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR002042; Uricase.
 IPR019842; Uricase_CS. 

Pfam

 PF01014; Uricase 

SMART

  

PROSITE

 PS00366; URICASE 

PRINTS

 PR00093; URICASE.