UniProt Accession

 HBB1_RAT; P02091; P33584 

Genbank Protein ID

 X16417; X15009; M17084; X67613; BC058448 

Genbank Nucleotide ID

 CAA34439.1; CAA33114.1; AAA41309.1; CAA47873.1; AAH58448.1 

Protein Name

 Hemoglobin subunit beta-1 

Protein Synonyms/Alias

 Beta-1-globin; Hemoglobin beta chain, major-form; Hemoglobin beta-1 chain 

Gene Name

 Hbb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
9	VHLTDAEKAAVNGLW	acetylation	[1]
18	AVNGLWGKVNPDDVG	acetylation	[1]
18	AVNGLWGKVNPDDVG	ubiquitination	[2]
60	SAIMGNPKVKAHGKK	acetylation	[1]
66	PKVKAHGKKVINAFN	acetylation	[1]
67	KVKAHGKKVINAFND	acetylation	[1]
67	KVKAHGKKVINAFND	ubiquitination	[2]
77	NAFNDGLKHLDNLKG	acetylation	[1]
77	NAFNDGLKHLDNLKG	ubiquitination	[2]
83	LKHLDNLKGTFAHLS	acetylation	[1]
96	LSELHCDKLHVDPEN	acetylation	[1]
133	CAQAAFQKVVAGVAS	acetylation	[1]
145	VASALAHKYH*****	acetylation	[1]
145	VASALAHKYH*****	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in oxygen transport from the lung to the various peripheral tissues. 

Sequence Annotation

 METAL 64 64 Iron (heme distal ligand).
 METAL 93 93 Iron (heme proximal ligand).
 MOD_RES 45 45 Phosphoserine (By similarity).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport; Phosphoprotein; Polymorphism; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005833; C:hemoglobin complex; IDA:RGD.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0031721; F:hemoglobin alpha binding; IDA:RGD.
 GO:0031722; F:hemoglobin beta binding; IDA:RGD.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IEA:InterPro.
 GO:0005344; F:oxygen transporter activity; IEA:UniProtKB-KW.
 GO:0006749; P:glutathione metabolic process; IDA:RGD.
 GO:0015671; P:oxygen transport; IDA:RGD.
 GO:0051291; P:protein heterooligomerization; IDA:RGD. 

Interpro

 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002337; Haemoglobin_b. 

Pfam

 PF00042; Globin 

SMART

  

PROSITE

 PS01033; GLOBIN 

PRINTS

 PR00814; BETAHAEM.