UniProt Accession

 KCY_YEAST; P15700; D6VXR0 

Genbank Protein ID

 M31455; M69295; Z28024; AY558074; BK006944 

Genbank Nucleotide ID

 AAA35194.1; AAA35200.1; CAA81859.1; AAS56400.1; DAA09130.1 

Protein Name

 Uridylate kinase 

Protein Synonyms/Alias

 UK; ATP:UMP phosphotransferase; Deoxycytidylate kinase; CK; dCMP kinase; Suppressor of cdc8 protein; Uridine monophosphate kinase; UMP kinase; UMPK 

Gene Name

 URA6 

Gene Synonyms/Alias

 SOC8; YKL024C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
67	SQYGELIKNCIKEGQ	acetylation	[1]
67	SQYGELIKNCIKEGQ	ubiquitination	[2]
99	NVKANKHKFLIDGFP	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP, AMP, GMP, dGMP and dTMP. ATP and dATP are the best phosphate donors, but can also use GTP, dGTP, dCTP, and dTTP to some degree. 

Sequence Annotation

 NP_BIND 26 31 ATP.
 NP_BIND 74 76 NMP.
 NP_BIND 104 107 NMP.
 REGION 46 76 NMPbind.
 REGION 141 151 LID.
 BINDING 52 52 NMP.
 BINDING 111 111 NMP.
 BINDING 142 142 ATP.
 BINDING 148 148 NMP.
 BINDING 159 159 NMP.
 BINDING 187 187 ATP; via carbonyl oxygen.  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Pyrimidine biosynthesis; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0004017; F:adenylate kinase activity; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004127; F:cytidylate kinase activity; IEA:EC.
 GO:0009041; F:uridylate kinase activity; IDA:SGD.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IDA:SGD.
 GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR000850; Adenylate_kin.
 IPR027417; P-loop_NTPase.
 IPR006266; UMP_CMP_kinase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.