| Tag | Content |
|---|
| CPLM ID | CPLM-021480 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pleckstrin homology domain-containing family G member 2 |
Protein Synonyms/Alias | PH domain-containing family G member 2 |
Gene Name | PLEKHG2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 386 | VSDLTIPKHRHLLQA | ubiquitination | [1] | | 394 | HRHLLQAKNQEEKRL | ubiquitination | [1] | | 421 | HPASIPAKAKQVLLE | ubiquitination | [1] | | 423 | ASIPAKAKQVLLENS | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein). |
Sequence Annotation | DOMAIN 102 283 DH.
DOMAIN 313 411 PH.
MOD_RES 445 445 Phosphothreonine.
MOD_RES 450 450 Phosphoserine.
MOD_RES 1257 1257 Phosphothreonine. |
Keyword | Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Polymorphism; Reference proteome; Tumor suppressor. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1386 AA |
Protein Sequence | MPEGAQGLSL SKPSPSLGCG RRGEVCDCGT VCETRTAPAA PTMASPRGSG SSTSLSTVGS 60
EGDPAPGPTP ACSASRPEPL PGPPIRLHLS PVGIPGSARP SRLERVAREI VETERAYVRD 120
LRSIVEDYLG PLLDGGVLGL SVEQVGTLFA NIEDIYEFSS ELLEDLENSS SAGGIAECFV 180
QRSEDFDIYT LYCMNYPSSL ALLRELSLSP PAALWLQERQ AQLRHSLPLQ SFLLKPVQRI 240
LKYHLLLQEL GKHWAEGPGT GGREMVEEAI VSMTAVAWYI NDMKRKQEHA ARLQEVQRRL 300
GGWTGPELSA FGELVLEGAF RGGGGGGPRL RGGERLLFLF SRMLLVAKRR GLEYTYKGHI 360
FCCNLSVSES PRDPLGFKVS DLTIPKHRHL LQAKNQEEKR LWIHCLQRLF FENHPASIPA 420
KAKQVLLENS LHCAPKSKPV LEPLTPPLGS PRPRDARSFT PGRRNTAPSP GPSVIRRGRR 480
QSEPVKDPYV MFPQNAKPGF KHAGSEGELY PPESQPPVSG SAPPEDLEDA GPPTLDPSGT 540
SITEEILELL NQRGLRDPGP STHDIPKFPG DSQVPGDSET LTFQALPSRD SSEEEEEEEE 600
GLEMDERGPS PLHVLEGLES SIAAEMPSIP CLTKIPDVPN LPEIPSRCEI PEGSRLPSLS 660
DISDVFEMPC LPAIPSVPNT PSLSSTPTLS CDSWLQGPLQ EPAEAPATRR ELFSGSNPGK 720
LGEPPSGGKA GPEEDEEGVS FTDFQPQDVT QHQGFPDELA FRSCSEIRSA WQALEQGQLA 780
RPGFPEPLLI LEDSDLGGDS GSGKAGAPSS ERTASRVREL ARLYSERIQQ MQRAETRASA 840
NAPRRRPRVL AQPQPSPCLP QEQAEPGLLP AFGHVLVCEL AFPLTCAQES VPLGPAVWVQ 900
AAIPLSKQGG SPDGQGLHVS NLPKQDLPGI HVSAATLLPE QGGSRHVQAP AATPLPKQEG 960
PLHLQVPALT TFSDQGHPEI QVPATTPLPE HRSHMVIPAP STAFCPEQGH CADIHVPTTP 1020
ALPKEICSDF TVSVTTPVPK QEGHLDSESP TNIPLTKQGG SRDVQGPDPV CSQPIQPLSW 1080
HGSSLDPQGP GDTLPPLPCH LPDLQIPGTS PLPAHGSHLD HRIPANAPLS LSQELPDTQV 1140
PATTPLPLPQ VLTDIWVQAL PTSPKQGSLP DIQGPAAAPP LPEPSLTDTQ VQKLTPSLEQ 1200
KSLIDAHVPA ATPLPERGGS LDIQGLSPTP VQTTMVLSKP GGSLASHVAR LESSDLTPPH 1260
SPPPSSRQLL GPNAAALSRY LAASYISQSL ARRQGPGGGA PAASRGSWSS APTSRASSPP 1320
PQPQPPPPPA RRLSYATTVN IHVGGGGRLR PAKAQVRLNH PALLASTQES MGLHRAQGAP 1380
DAPFHM 1386 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. GO:0097190; P:apoptotic signaling pathway; TAS:Reactome. GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome. GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome. GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |