CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002798
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SWI/SNF chromatin-remodeling complex subunit SWI1 
Protein Synonyms/Alias
 Regulatory protein GAM3; SWI/SNF complex subunit SWI1; Transcription regulatory protein ADR6; Transcription regulatory protein SWI1 
Gene Name
 SWI1 
Gene Synonyms/Alias
 ADR6; GAM3; YPL016W; LPA1 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
684YDINYISKIGEKIDSacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Involved in transcriptional activation. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors. 
Sequence Annotation
 DOMAIN 406 493 ARID.
 ZN_FING 1241 1258 C4-type.
 REGION 1 323 Prion domain (PrD).  
Keyword
 3D-structure; Activator; Amyloid; Complete proteome; DNA-binding; Metal-binding; Nucleus; Prion; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1314 AA 
Protein Sequence
MDFFNLNNNN NNNNTTTTTT TTNNNNTNNN NTNNNNNPAN NTNNNNSTGH SSNTNNNTNN 60
NNTNTGASGV DDFQNFFDPK PFDQNLDSNN NNSNSNNNDN NNSNTVASST NFTSPTAVVN 120
NAAPANVTGG KAANFIQNQS PQFNSPYDSN NSNTNLNSLS PQAILAKNSI IDSSNLPLQA 180
QQQLYGGNNN NNSTGIANDN VITPHFITNV QSISQNSSSS TPNTNSNSTP NANQQFLPFN 240
NSASNNGNLT SNQLISNYAA SNSMDRSSSA SNEFVPNTSD NNNNSNNHNM RNNSNNKTSN 300
NNNVTAVPAA TPANTNNSTS NANTVFSERA AMFAALQQKQ QQRFQALQQQ QQQQQNQQQQ 360
NQQPQQQQQQ QQNPKFLQSQ RQQQQRSILQ SLNPALQEKI STELNNKQYE LFMKSLIENC 420
KKRNMPLQSI PEIGNRKINL FYLYMLVQKF GGADQVTRTQ QWSMVAQRLQ ISDYQQLESI 480
YFRILLPYER HMISQEGIKE TQAKRIFLQQ FLQELLKKVQ QQQQAAALAN ANNNINSASS 540
APTPAAPGAS VPATAAPGTE AGIVPVSANT PKSLNSNINI NVNNNNIGQQ QVKKPRKQRV 600
KKKTKKELEL ERKEREDFQK RQQKLLEDQQ RQQKLLLETK LRQQYEIELK KLPKVYKRSI 660
VRNYKPLINR LKHYNGYDIN YISKIGEKID SNKPIFLFAP ELGAINLHAL SMSLQSKNLG 720
EINTALNTLL VTSADSNLKI SLVKYPELLD SLAILGMNLL SNLSQNVVPY HRNTSDYYYE 780
DAGSNQYYVT QHDKMVDKIF EKVNNNATLT PNDSNDEKVT ILVDSLTGNQ LPTPTPTEME 840
PDLDTECFIS MQSTSPAVKQ WDLLPEPIRF LPNQFPLKIH RTPYLTSLKK IKDEIDDPFT 900
KINTRGAEDP KVLINDQLST ISMILRNISF SDNNSRIMSR NFYLKRFISD LLWLVLIHPE 960
NFTCNRKILN FKKDLVIVLS NISHLLEIAS SIDCLLILIL VISFGQPKLN PMASSSSFGS 1020
ESLTFNEFQL QWGKYQTFGV DILAKLFSLE KPNLNYFKSI LLNKNTGNNL YDRNSNNNHK 1080
DKKLLRRLLN LYNDNNKNNN NRHNLLNDVV SFLFSAIPLQ QVLSQSADPS LLIDQFSPVI 1140
SQSLTSILVI VQKILPLSNE VFEISENNSD SNSNNNGNKD SSFNFNKNLP FVWLSSEENI 1200
GSGLLKLSEI ILNINNSTSK NTLLQQQNYS KVLLPSINIS CVQLIKCLVE KSICFENCLN 1260
NDPEILKKIA SIPNLFPTDL EIFQLFTNPS VDIQIINQYQ LLYNLKNDIL TNLE 1314 
Gene Ontology
 GO:0016514; C:SWI/SNF complex; IDA:SGD.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0001102; F:RNA polymerase II activating transcription factor binding; IMP:SGD.
 GO:0043044; P:ATP-dependent chromatin remodeling; IDA:SGD.
 GO:0000436; P:carbon catabolite activation of transcription from RNA polymerase II promoter; IGI:SGD.
 GO:0044109; P:cellular alcohol catabolic process; IMP:SGD.
 GO:0006261; P:DNA-dependent DNA replication; IMP:SGD.
 GO:0031496; P:positive regulation of mating type switching; IMP:SGD.
 GO:0061412; P:positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation; IMP:SGD.
 GO:0005987; P:sucrose catabolic process; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001606; ARID/BRIGHT_DNA-bd. 
Pfam
 PF01388; ARID 
SMART
 SM00501; BRIGHT 
PROSITE
 PS51011; ARID 
PRINTS