CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041303
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DENN domain-containing protein 5B 
Protein Synonyms/Alias
 Putative uncharacterized protein MGC24039 
Gene Name
 DENND5B 
Gene Synonyms/Alias
 MGC24039; hCG_1810950 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
93LRRTFKSKVLAHYPQubiquitination[1]
456SESTSKLKNMVLKDLubiquitination[1, 2]
461KLKNMVLKDLVNDKKubiquitination[3]
484ISMYELLKGNETIARubiquitination[1]
517ASLGEKDKDLKLHCEubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1309 AA 
Protein Sequence
MGTHHHAQLI FVFLVEMRFH HVDQAGLELL TSSNSPASAS RSAEITVVSQ HAQPGFLYQW 60
LEADRHGKSQ GAANTTSGEN FDQSPLRRTF KSKVLAHYPQ NIEWNPFDQD AVNMLCMPKG 120
LSFRTQTDNK DPQFHSFIIT REDGSRTYGF VLTFYEEVTS KQICTAMQTL YQMHNAEHYS 180
SVYASSSCSM DSLASSLDEG DTTSLLKLQR YNSYDISRDT LYVSKSICLI TPLPFMQACK 240
KFLIQLYKAV TSQQPPPLPL ESYIHNILYE VPLPPPGRSL KFYGVYEPVI CQRPGPSELP 300
LSDYPLREAF ELLGLENLVQ VFTCVLLEMQ ILLYSQDYQR LMTVAEGITT LLFPFQWQHV 360
YVPILPASLL HFLDAPVPYL MGLQSKEGTD RSKLELPQEA NLCFVDIDNH FIELPEEFPQ 420
FPNKVDFIQE LSEVLVQFGI PPEGSLHCSE STSKLKNMVL KDLVNDKKNG NVCTNNISMY 480
ELLKGNETIA RLQALAKRTG VAVEKMDLSA SLGEKDKDLK LHCEEAELRD YQLNVQLREV 540
FANRFTQMFA DYEAFVIQTA QDMESWLTNR EQMQNFDKAS FLSDQPEPYL PFLSRFIETQ 600
MFATFIDNKI MSQWEEKDPL LRVFDTRIDK IRLYNVRAPT LRTSIYQKCS TLKEAAQSIE 660
QRLMKMDHTA IHPHLLDMKI GQGKYEQGFF PKLQSDVLAT GPTSNNRWVS RSATAQRRKE 720
RLRQHSEHVG LDNDLREKYM QEARSLGKNL RQPKLSDLSP AVIAQTNCKF VEGLLKECRM 780
KTKRMLVEKM GHEAVELGHG EANITGLEEN TLIASLCDLL ERIWSHGLQV KQGKSALWSH 840
LIQFQDREEK QEHLAESPVA LGPERRKSDS GVMLPTLRVS LIQDMRHIQN MSEIKTDVGR 900
ARAWIRLSLE KKLLSQHLKQ LLSNQPLTKK LYKRYAFLRC EEEREQFLYH LLSLNAVDYF 960
CFTSVFTTIM IPYRSVIIPI KKLSNAIITS NPWICVSGEL GDTGVMQIPK NLLEMTFECQ 1020
NLGKLTTVQI GHDNSGLLAK WLVDCVMVRN EITGHTYRFP CGRWLGKGID DGSLERILIG 1080
ELMTSASDED LVKQCRTPPQ QKSPTTARRL SITSLTGKNN KPNAGQIQEG IGEAVNNIVK 1140
HFHKPEKERG SLTVLLCGEN GLVAALEQVF HHGFKSARIF HKNVFIWDFI EKVVAYFETT 1200
DQILDNEDDV LIQKSSCKTF CHYVNAINTA PRNIGKDGKF QILVCLGTRD RLLPQWIPLL 1260
AECPAITRMY EESALLRDRM TVNSLIRILQ TIQDFTIVLE GSLIKGVDV 1309 
Gene Ontology
  
Interpro
 IPR005112; dDENN_dom.
 IPR001194; DENN_dom.
 IPR008976; Lipase_LipOase.
 IPR001024; LipOase_LH2.
 IPR004012; Run.
 IPR005113; uDENN_dom. 
Pfam
 PF03455; dDENN
 PF02141; DENN
 PF01477; PLAT
 PF02759; RUN
 PF03456; uDENN 
SMART
 SM00801; dDENN
 SM00799; DENN
 SM00593; RUN
 SM00800; uDENN 
PROSITE
 PS50947; DDENN
 PS50211; DENN
 PS50095; PLAT
 PS50826; RUN
 PS50946; UDENN 
PRINTS