CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014951
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type II cytoskeletal 1b 
Protein Synonyms/Alias
 Cytokeratin-1B; CK-1B; Keratin-77; K77; Type-II keratin Kb39 
Gene Name
 Krt77 
Gene Synonyms/Alias
 Kb39; Krt1b 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
276NDFVVLKKDVDAAFMacetylation[1]
373ELQITAGKHGDDLKNacetylation[1]
403QAEIANIKKQIEQMHacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
 REGION 1 166 Head.
 REGION 167 476 Rod.
 REGION 167 202 Coil 1A.
 REGION 203 221 Linker 1.
 REGION 222 313 Coil 1B.
 REGION 314 337 Linker 12.
 REGION 338 476 Coil 2.
 REGION 477 519 Tail.
 MOD_RES 64 64 Phosphoserine (By similarity).
 MOD_RES 73 73 Phosphoserine (By similarity).
 MOD_RES 75 75 Phosphoserine (By similarity).
 MOD_RES 253 253 Phosphotyrosine (By similarity).  
Keyword
 Citrullination; Coiled coil; Complete proteome; Intermediate filament; Keratin; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 519 AA 
Protein Sequence
MSRQFSSQSA FSSRSRRVYS TRSSSGFGGG RQILVSVGQS RRCGGDYGGG FSSRSLYSLG 60
GSKSIFGGLV GRSASGFCQS RGAGGGFGGG FGGGRSFGGG GFGGGYGGGG RFGGGFGGGF 120
GTSNFGLGGF GPSYPPGGIH EVTVNQSLLE PLHLEVDPEI QKIKTQEREQ IKTLNNKFAS 180
FIDKVRFLEQ QNQVLQTKWE LLQQVNTSTR TSSLEPIFEE FINQLQRQVD VLTNEQLRQN 240
SEIRSMQDIV EDYKNKYEDE INKRTNSEND FVVLKKDVDA AFMAKSDLQS RVDTLYGEIN 300
FLKYLFDTEL SQIQTHVSDT NVILSMDNNR SLDLDSIINA VRTQYELIAQ KSKDEAEALY 360
QTKYQELQIT AGKHGDDLKN SKMEISELNR NAQRLQAEIA NIKKQIEQMH GSISDAEERG 420
ERALQDAKQK LQETEEALQQ MKEDLARLLR DYQALLGAKL SLDVEIATYR ELLEGEESRM 480
SGALQSQVSI WALPSNEGND LGERLHDPQS QVPVPKLGC 519 
Gene Ontology
 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR003054; Keratin_II. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01276; TYPE2KERATIN.