UniProt Accession

 CLC7A_HUMAN; Q9BXN2; B2R861; B7Z494; B7Z5A9; B7Z5B9; Q6IPS7; Q96D32; Q96DR9; Q96LD3; Q96PA4; Q96PA5; Q96PA6; Q96PA7; Q96PA8; Q9H1K3 

Genbank Protein ID

 AY026769; AY026770; AY026771; AF313468; AF313469; AF400595; AF400596; AF400597; AF400598; AF400599; AF400600; AF400601; AF400602; AJ312372; AJ312373; AY009090; AY359002; AK297028; AK298679; AK298724; AK313247; AC024224; CH471094; CH471094; CH471094; CH471094; CH471094; BC013385; BC071746; BC093829; BC093831 

Genbank Nucleotide ID

 AAK20114.2; AAK20115.1; AAK20116.1; AAK37473.1; AAK37474.1; AAL11711.1; AAL11712.1; AAL11713.1; AAL11714.1; AAL11715.1; AAL11716.1; AAL11717.1; AAL11718.1; CAC43846.1; CAC43847.1; AAG33923.2; AAQ89361.1; BAH12480.1; BAH12845.1; BAH12855.1; BAG36058.1; EAW96144.1; EAW96145.1; EAW96146.1; EAW96150.1; EAW96154.1; AAH13385.1; AAH71746.1; AAH93829.1; AAH93831.1 

Protein Name

 C-type lectin domain family 7 member A 

Protein Synonyms/Alias

 Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1 

Gene Name

 CLEC7A 

Gene Synonyms/Alias

 BGR; CLECSF12; DECTIN1; UNQ539/PRO1082 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
111	VTPTKAVKTTGVLSS	ubiquitination	[1]
157	QLGSNLLKIDSSNEL	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). 

Sequence Annotation

 DOMAIN 127 242 C-type lectin.
 MOTIF 15 18 ITAM-like.
 METAL 157 157 Divalent metal cation (By similarity).
 METAL 159 159 Divalent metal cation (By similarity).
 METAL 163 163 Divalent metal cation (By similarity).
 METAL 242 242 Divalent metal cation (By similarity).
 CARBOHYD 91 91 N-linked (GlcNAc...) (Potential).
 DISULFID 120 131 By similarity.
 DISULFID 148 241 By similarity.
 DISULFID 220 233 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Disulfide bond; Glycoprotein; Immunity; Inflammatory response; Innate immunity; Lectin; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 247 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; TAS:UniProtKB.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0030246; F:carbohydrate binding; IDA:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0042287; F:MHC protein binding; NAS:UniProtKB.
 GO:0008329; F:signaling pattern recognition receptor activity; IDA:UniProtKB.
 GO:0009756; P:carbohydrate mediated signaling; TAS:UniProtKB.
 GO:0042832; P:defense response to protozoan; NAS:UniProtKB.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0006910; P:phagocytosis, recognition; IDA:UniProtKB.
 GO:0042110; P:T cell activation; TAS:UniProtKB. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold. 

Pfam

 PF00059; Lectin_C 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS