CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015725
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fructose-bisphosphate aldolase 
Protein Synonyms/Alias
  
Gene Name
 PF14_0425 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Plasmodium falciparum (isolate 3D7) 
NCBI Taxa ID
 36329 
Lysine Modification
Position
Peptide
Type
References
54KKRFDNIKLENTIENacetylation[1]
348NSLATYGKYKGGAGGacetylation[1]
365AGASLYEKKYVY***acetylation[1]
Reference
 [1] Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development.
 Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L.
 Mol Microbiol. 2013 Aug;89(4):660-75. [PMID: 23796209] 
Functional Description
  
Sequence Annotation
 ACT_SITE 195 195 Proton acceptor (By similarity).
 ACT_SITE 237 237 Schiff-base intermediate with
 BINDING 62 62 Substrate (By similarity).
 BINDING 152 152 Substrate (By similarity).  
Keyword
 Complete proteome; Glycolysis; Lyase; Reference proteome; Schiff base. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 369 AA 
Protein Sequence
MAHCTEYMNA PKKLPADVAE ELATTAQKLV QAGKGILAAD ESTQTIKKRF DNIKLENTIE 60
NRASYRDLLF GTKGLGKFIS GAILFEETLF QKNEAGVPMV NLLHNENIIP GIKVDKGLVN 120
IPCTDEEKST QGLDGLAERC KEYYKAGARF AKWRTVLVID TAKGKPTDLS IHETAWGLAR 180
YASICQQNRL VPIVEPEILA DGPHSIEVCA VVTQKVLSCV FKALQENGVL LEGALLKPNM 240
VTAGYECTAK TTTQDVGFLT VRTLRRTVPP ALPGVVFLSG GQSEEEASVN LNSINALGPH 300
PWALTFSYGR ALQASVLNTW QGKKENVAKA REVLLQRAEA NSLATYGKYK GGAGGENAGA 360
SLYEKKYVY 369 
Gene Ontology
 GO:0004332; F:fructose-bisphosphate aldolase activity; IEA:EC.
 GO:0006094; P:gluconeogenesis; TAS:GeneDB_Pfalciparum.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR000741; Aldolase_I.
 IPR013785; Aldolase_TIM. 
Pfam
 PF00274; Glycolytic 
SMART
  
PROSITE
 PS00158; ALDOLASE_CLASS_I 
PRINTS