CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030637
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ46359 fis, clone TESTI4049786, highly similar to Hexokinase-1 (EC 2.7.1.1) 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
222VEGADVVKLLNKAIKubiquitination[1]
368PELLTRGKFNTSDVSubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Glycolysis; Kinase; Nucleotide-binding; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 952 AA 
Protein Sequence
MGQICQRESR QGLAMLPRLF LNPWRQVILL PQPPKVLGLQ ATAAEKPKLH LLAESEIDKY 60
LYAMRLSDET LIDIMTRFRK EMKNGLSRDF NPTATVKMLP TFVRPIPDGS EKGDFIALDL 120
GGSSFRILRV QVNHEKNQNV HMESEVYDTP ENIVHGSGSQ LFDHVAECLG DFMEKRKIKD 180
KKLPVGFTFS FPCQQSKIDE AILITWTKRF KASGVEGADV VKLLNKAIKK RGDYDANIVA 240
VVNDTVGTMM TCGYDDQHCE VGLIIGTGTN ACYMEELRHI DLVEGDEGRM CINTEWGAFG 300
DDGSLEDIRT EFDREIDRGS LNPGKQLFEK MVSGMYLGEL VRLILVKMAK EGLLFEGRIT 360
PELLTRGKFN TSDVSAIEKN KEGLHNAKEI LTRLGVEPSD DDCVSVQHVC TIVSFRSANL 420
VAATLGAILN RLRDNKGTPR LRTTVGVDGS LYKTHPQYSR RFHKTLRRLV PDSDVRFLLS 480
ESGSGKGAAM VTAVAYRLAE QHRQIEETLA HFHLTKDMLL EVKKRMRAEM ELGLRKQTHN 540
NAVVKMLPSF VRRTPDGTEN GDFLALDLGG TNFRVLLVKI RSGKKRTVEM HNKIYAIPIE 600
IMQGTGEELF DHIVSCISDF LDYMGIKGPR MPLGFTFSFP CQQTSLDAGI LITWTKGFKA 660
TDCVGHDVVT LLRDAIKRRE EFDLDVVAVV NDTVGTMMTC AYGEPTCEVG LIVGTGSNAC 720
YMEEMKNVEM VEGDQGQMCI NMEWGAFGDN GCLDDIRTHY DRLVDEYSLN AGKQRYEKMI 780
SGMYLGEIVR NILIDFTKKG FLFRGQISET LKTRGIFETK FLSQIESDRL ALLQVRAILQ 840
QLGLNSTCDD SILVKTVCGV VSRRAAQLCG AGMAAVVDKI RENRGLDRLN VTVGVDGTLY 900
KLHPHFSRIM HQTVKELSPK CNVSFLLSED GSGKGAALIT AVGVRLRTEA SS 952 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004396; F:hexokinase activity; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001312; Hexokinase.
 IPR022673; Hexokinase_C.
 IPR019807; Hexokinase_CS.
 IPR022672; Hexokinase_N. 
Pfam
 PF00349; Hexokinase_1
 PF03727; Hexokinase_2 
SMART
  
PROSITE
 PS00378; HEXOKINASES 
PRINTS
 PR00475; HEXOKINASE.