UniProt Accession

 GPM6A_MOUSE; P35802 

Genbank Protein ID

 S65735; BC024759; BC029683; BC029711; BC033357; BC033394; BC043130 

Genbank Nucleotide ID

 AAB28350.1; AAH24759.1; AAH29683.1; AAH29711.1; AAH33357.1; AAH33394.1; AAH43130.1 

Protein Name

 Neuronal membrane glycoprotein M6-a 

Protein Synonyms/Alias

 M6a 

Gene Name

 Gpm6a 

Gene Synonyms/Alias

 M6a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
250	KDACRMQKYEDIKSK	ubiquitination	[1]
255	MQKYEDIKSKEEQEL	ubiquitination	[1]
257	KYEDIKSKEEQELHD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-indepenedent membrane deformation. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. 

Sequence Annotation

 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 208 208 N-linked (GlcNAc...) (Potential).
 DISULFID 174 192 By similarity.  

Keyword

 Cell membrane; Cell projection; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Neurogenesis; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 278 AA 

Protein Sequence

Gene Ontology

 GO:0044295; C:axonal growth cone; IDA:UniProtKB.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0030175; C:filopodium; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0005262; F:calcium channel activity; IEA:Compara.
 GO:0003407; P:neural retina development; IDA:UniProtKB.
 GO:0001764; P:neuron migration; ISS:UniProtKB.
 GO:0048812; P:neuron projection morphogenesis; IDA:UniProtKB.
 GO:0051491; P:positive regulation of filopodium assembly; ISS:UniProtKB.
 GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
 GO:0007416; P:synapse assembly; ISS:UniProtKB. 

Interpro

 IPR001614; Myelin_PLP.
 IPR018237; Myelin_PLP_CS. 

Pfam

 PF01275; Myelin_PLP 

SMART

 SM00002; PLP 

PROSITE

 PS00575; MYELIN_PLP_1
 PS01004; MYELIN_PLP_2 

PRINTS

 PR00214; MYELINPLP.