| Tag | Content |
|---|
| CPLM ID | CPLM-012746 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Receptor-type tyrosine-protein phosphatase-like N |
Protein Synonyms/Alias | R-PTP-N; Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2 |
Gene Name | PTPRN |
Gene Synonyms/Alias | ICA3; ICA512 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 754 | DHARIKLKVESSPSR | sumoylation | [1] |
|
Reference | [1] Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5. Mziaut H, Trajkovski M, Kersting S, Ehninger A, Altkrüger A, Lemaitre RP, Schmidt D, Saeger HD, Lee MS, Drechsel DN, Müller S, Solimena M. Nat Cell Biol. 2006 May;8(5):435-45. [ PMID: 16622421] |
Functional Description | Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. |
Sequence Annotation | DOMAIN 709 969 Tyrosine-protein phosphatase.
REGION 909 915 Substrate binding (By similarity).
ACT_SITE 909 909 Phosphocysteine intermediate (By
CARBOHYD 441 441 O-linked (GalNAc...).
CARBOHYD 506 506 N-linked (GlcNAc...) (Potential).
CARBOHYD 524 524 N-linked (GlcNAc...) (Potential). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 979 AA |
Protein Sequence | MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG 60
QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE 120
PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL 180
LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA 240
PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG 300
SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL 360
LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE 420
VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP 480
LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE 540
LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV 600
RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ 660
FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ 720
AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY 780
IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV 840
SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG 900
RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE 960
FALTAVAEEV NAILKALPQ 979 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc. GO:0000302; P:response to reactive oxygen species; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |