UniProt Accession

 CCND2_HUMAN; P30279; A8K531; Q13955; Q5U035 

Genbank Protein ID

 M90813; X68452; D13639; BT019847; AF518005; AK291146; CH471116; BC010958; BC089384; M88083; M88080; M88081; M88082 

Genbank Nucleotide ID

 AAA51926.1; CAA48493.1; BAA02802.1; AAV38650.1; AAM54041.1; BAF83835.1; EAW88851.1; AAH10958.1; AAH89384.1; AAA51928.1; AAA51928.1; AAA51928.1; AAA51928.1 

Protein Name

 G1/S-specific cyclin-D2 

Protein Synonyms/Alias

  

Gene Name

 CCND2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
45	LPQCSYFKCVQKDIQ	ubiquitination	[1, 2]
49	SYFKCVQKDIQPYMR	ubiquitination	[3]
113	MFLASKLKETSPLTA	ubiquitination	[3]
148	LVVLGKLKWNLAAVT	ubiquitination	[3]
244	NTDVDCLKACQEQIE	ubiquitination	[3]
270	QDQRDGSKSEDELDQ	ubiquitination	[3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). 

Sequence Annotation

 DOMAIN 26 151 Cyclin N-terminal.  

Keyword

 Cell cycle; Cell division; Complete proteome; Cyclin; Cytoplasm; Membrane; Nucleus; Polymorphism; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IDA:UniProtKB.
 GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IDA:UniProtKB.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0031965; C:nuclear membrane; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0045737; P:positive regulation of cyclin-dependent protein kinase activity; IDA:BHF-UCL. 

Interpro

 IPR013763; Cyclin-like.
 IPR014400; Cyclin_A/B/D/E.
 IPR004367; Cyclin_C-dom.
 IPR006671; Cyclin_N. 

Pfam

 PF02984; Cyclin_C
 PF00134; Cyclin_N 

SMART

 SM00385; CYCLIN 

PROSITE

 PS00292; CYCLINS 

PRINTS