UniProt Accession

 PHX2A_HUMAN; O14813; A8K3N0; Q8IVZ2 

Genbank Protein ID

 AF022724; AF022722; AF022723; AK290645; CH471076; BC041564 

Genbank Nucleotide ID

 AAB82744.1; AAB82744.1; AAB82744.1; BAF83334.1; EAW74856.1; AAH41564.1 

Protein Name

 Paired mesoderm homeobox protein 2A 

Protein Synonyms/Alias

 ARIX1 homeodomain protein; Aristaless homeobox protein homolog; Paired-like homeobox 2A 

Gene Name

 PHOX2A 

Gene Synonyms/Alias

 ARIX; PMX2A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
76	PYSAVPYKFFPEPSG	ubiquitination	[1]
87	EPSGLHEKRKQRRIR	ubiquitination	[1]
155	QERAASAKGAAGAAG	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. 

Sequence Annotation

 DNA_BIND 90 149 Homeobox.  

Keyword

 Activator; Complete proteome; Disease mutation; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:ProtInc.
 GO:0071542; P:dopaminergic neuron differentiation; IC:BHF-UCL.
 GO:0021703; P:locus ceruleus development; IEA:Compara.
 GO:0030901; P:midbrain development; IEA:Compara.
 GO:0003357; P:noradrenergic neuron differentiation; NAS:BHF-UCL.
 GO:0021623; P:oculomotor nerve formation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0043576; P:regulation of respiratory gaseous exchange; IEA:Compara.
 GO:0021523; P:somatic motor neuron differentiation; IEA:Compara.
 GO:0048485; P:sympathetic nervous system development; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0021642; P:trochlear nerve formation; IEA:Compara. 

Interpro

 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS