Tag | Content |
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CPLM ID | CPLM-014482 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Liver carboxylesterase B-1 |
Protein Synonyms/Alias | Liver microsomal carboxylesterase |
Gene Name | |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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304 | MEKMNLIKLSSQRDT | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. |
Sequence Annotation | MOTIF 558 561 Prevents secretion from ER (Potential). ACT_SITE 221 221 Acyl-ester intermediate (By similarity). ACT_SITE 353 353 Charge relay system (By similarity). ACT_SITE 466 466 Charge relay system (By similarity). CARBOHYD 79 79 N-linked (GlcNAc...) (Potential). DISULFID 87 116 By similarity. DISULFID 273 284 By similarity. |
Keyword | Complete proteome; Direct protein sequencing; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Hydrolase; Reference proteome; Serine esterase; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 561 AA |
Protein Sequence | MCLRSLFLVS LATCVVCGNP SSPPVVDTMK GKVLGKYASL EGVTQSVAVF LGVPFAKPPL 60 GSLRFAPPQP AEPWSFVKNT TTYPPMCSQD ATKGQRMNDL LTNRKEKVHL QFSEDCLYLN 120 IYTPADFTKD SRMPVMVWIH GGGLTQGGAS TYDGQVLSAY ENVVVVAIQY RLGIWGFFST 180 GDEHSRGNWG HLDQVAALHW VQDNIANFGG DPGSVTIFGE SAGGFSVSVL VLSPLSKNLY 240 HRAISESGVV LITELFTKDV RPAAKQIADM AGCKTTTSAI IVHCLRQKTE EELLEIMEKM 300 NLIKLSSQRD TKESYHFLST VIDDVVLPKD PKEILAEKNF NTVPYIVGIN KQECGWLLPT 360 MMRFVPPDVK LDKKMAIMLL EKFASIYGIP EDIIPVAIEK YRKGSDDPIK IRDGILAFIG 420 DVLFCIPSVM VSRDHRDAGA PTYVYEYQYY PSFSSPQRPK DVVGDHADDV YSVFGAPILR 480 DGASEEEIKL SKMVMKFWAN FARNGNPNAR GLPHWPQYDQ KEEYLQIGAT TQQSQRLKAE 540 EVAFWTQLLA KRQPQPHHNE L 561 |
Gene Ontology | GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW. GO:0080030; F:methyl indole-3-acetate esterase activity; IEA:EC. GO:0080032; F:methyl jasmonate esterase activity; IEA:EC. GO:0080031; F:methyl salicylate esterase activity; IEA:EC. GO:0050253; F:retinyl-palmitate esterase activity; IEA:EC. |
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