| Tag | Content |
|---|
| CPLM ID | CPLM-016068 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kin of IRRE-like protein 1 |
Protein Synonyms/Alias | Kin of irregular chiasm-like protein 1; Nephrin-like protein 1 |
Gene Name | Kirrel |
Gene Synonyms/Alias | Kirrel1; Neph1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 614 | FKDDVDLKQDLRCDT | ubiquitination | [1] | | 631 | TREEYEMKDPTNGYY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. |
Sequence Annotation | DOMAIN 49 147 Ig-like C2-type 1.
DOMAIN 152 248 Ig-like C2-type 2.
DOMAIN 255 331 Ig-like C2-type 3.
DOMAIN 340 419 Ig-like C2-type 4.
DOMAIN 424 520 Ig-like C2-type 5.
MOTIF 437 439 Cell attachment site (Potential).
MOD_RES 637 637 Phosphotyrosine; by FYN (By similarity).
MOD_RES 638 638 Phosphotyrosine; by FYN (By similarity).
MOD_RES 654 654 Phosphotyrosine (By similarity).
MOD_RES 657 657 Phosphotyrosine (By similarity).
MOD_RES 756 756 Phosphotyrosine (By similarity).
CARBOHYD 78 78 N-linked (GlcNAc...) (Potential).
CARBOHYD 172 172 N-linked (GlcNAc...) (Potential).
CARBOHYD 329 329 N-linked (GlcNAc...).
CARBOHYD 503 503 N-linked (GlcNAc...) (Potential).
DISULFID 74 132 By similarity.
DISULFID 175 232 By similarity.
DISULFID 276 319 By similarity.
DISULFID 361 403 By similarity.
DISULFID 445 504 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 789 AA |
Protein Sequence | MTLESPSTRL MTCQSSLLPE KPRFLSQKMW APHLVVAYLI FVTLALALPG TQTRFSQEPA 60
DQTVVAGQRA VLPCVLLNYS GIVQWTKDGL ALGMGQGLKA WPRYRVVGSA DAGQYNLEIT 120
DAELSDDASY ECQATEAALR SRRAKLTVLI PPEETRIDGG PVILLQAGTP YNLTCRAFNA 180
KPAATIIWFR DGTQQEGAVT STELLKDGKR ETTISQLLIE PTDLDIGRVF TCRSMNEAIP 240
NGKETSIELD VHHPPTVTLS IEPQTVLEGE RVIFTCQATA NPEILGYRWA KGGFLIEDAH 300
ESRYETNVDY SFFTEPVSCE VYNKVGSTNV STLVNVHFAP RIVVYPKPTT TDIGSDVTLT 360
CVWVGNPPLT LTWTKKDSNM VLSNSNQLLL KSVTQADAGT YTCRAIVPRI GVAEREVPLY 420
VNGPPIISSE AVQFAVRGDG GKVECFIGST PPPDRIAWAW KENFLEVGTL ERYTVERTNS 480
GSGVLSTLTI NNVMEADFQT HYNCTAWNSF GPGTAIIQLE EREVLPVGII AGATIGAGIL 540
VVFSFAALVF FLYRRRKGSR KDVTLRKLDI KVETVNREPL TMHSDREDDT ASISTATRVM 600
KAIYSSFKDD VDLKQDLRCD TIDTREEYEM KDPTNGYYNV RAHEDRPSSR AVLYADYRAP 660
GPTRFDGRPS SRLSHSSGYA QLNTYSRAPA SDYGTEPTPS GPSAPGGTDT TSQLSYENYE 720
KFNSHPFPGA AGYPTYRLGY PQAPPSGLER TPYEAYDPIG KYATATRFSY TSQHSDYGQR 780
FQQRMQTHV 789 |
Gene Ontology | GO:0005911; C:cell-cell junction; IDA:MGI. GO:0043198; C:dendritic shaft; IDA:MGI. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara. GO:0005886; C:plasma membrane; IDA:MGI. GO:0016337; P:cell-cell adhesion; IDA:MGI. GO:0007588; P:excretion; IMP:MGI. GO:0001933; P:negative regulation of protein phosphorylation; IGI:MGI. GO:0030838; P:positive regulation of actin filament polymerization; IGI:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |