CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044568
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cadherin-3 
Protein Synonyms/Alias
  
Gene Name
 CDH3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
627LLVRKKRKIKEPLLLubiquitination[1, 2]
629VRKKRKIKEPLLLPEubiquitination[1, 2]
763EWGSRFKKLADMYGGubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Cadherins are calcium dependent cell adhesion proteins (By similarity). 
Sequence Annotation
  
Keyword
 Calcium; Cell adhesion; Cell membrane; Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 774 AA 
Protein Sequence
MGCPGQEPAL FSTDNDDFTV RNGETVQERR SLKERNPLKI FPSKRILRRH KRDWVVAPIS 60
VPENGKGPFP QRLNQLKSNK DRDTKIFYSI TGPGADSPPE GVFAVEKETG WLLLNKPLDR 120
EEIAKYELFG HAVSENGASV EDPMNISIIV TDQNDHKPKF TQDTFRGSVL EGVLPGTSVM 180
QVTATDEDDA IYTYNGVVAY SIHSQEPKDP HDLMFTIHRS TGTISVISSG LDREKVPEYT 240
LTIQATDMDG DGSTTTAVAV VEILDANDNA PMFDPQKYEA HVPENAVGHE VQRLTVTDLD 300
APNSPAWRAT YLIMGGDDGD HFTITTHPES NQGILTTRKG LDFEAKNQHT LYVEVTNEAP 360
FVLKLPTSTA TIVVHVEDVN EAPVFVPPSK VVEVQEGIPT GEPVCVYTAE DPDKENQKIS 420
YRILRDPAGW LAMDPDSGQV TAVGTLDRED EQFVRNNIYE VMVLAMDNGS PPTTGTGTLL 480
LTLIDVNDHG PVPEPRQITI CNQSPVRQVL NITDKDLSPH TSPFQAQLTD DSDIYWTAEV 540
NEEGDTVVLS LKKFLKQDTY DVHLSLSDHG NKEQLTVIRA TVCDCHGHVE TCPGPWKGGF 600
ILPVLGAVLA LLFLLLVLLL LVRKKRKIKE PLLLPEDDTR DNVFYYGEEG GGEEDQDYDI 660
TQLHRGLEAR PEVVLRNDVA PTIIPTPMYR PRPANPDEIG NFIIENLKAA NTDPTAPPYD 720
TLLVFDYEGS GSDAASLSSL TSSASDQDQD YDYLNEWGSR FKKLADMYGG GEDD 774 
Gene Ontology
 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0007156; P:homophilic cell adhesion; IEA:InterPro. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS.
 IPR000233; Cadherin_cytoplasmic-dom.
 IPR027397; Catenin_binding_dom. 
Pfam
 PF00028; Cadherin
 PF01049; Cadherin_C 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.