CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004675
UniProt Accession
Genbank Protein ID
 X52783 
Genbank Nucleotide ID
Protein Name
 Proteasome subunit beta type-1 
Protein Synonyms/Alias
 Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chain 
Gene Name
 Psmb1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
163SYQRDSFKAGGSASAacetylation[1]
203DRAMRLVKDVFISAAacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. 
Sequence Annotation
 MOD_RES 149 149 Phosphotyrosine (By similarity).
 MOD_RES 203 203 N6-acetyllysine (By similarity).
 CARBOHYD 57 57 O-linked (GlcNAc...) (By similarity).
 CARBOHYD 208 208 O-linked (GlcNAc...) (By similarity).  
Keyword
 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Hydrolase; Nucleus; Phosphoprotein; Protease; Proteasome; Reference proteome; Threonine protease. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 240 AA 
Protein Sequence
MLSTAAYRDP DRELVMGPQG SAGPVQMRFS PYAFNGGTVL AIAGEDFSIV ASDTRLSEGF 60
SIHTRDSPKC YKLTDKTVIG CSGFHGDCLT LTKIIEARLK MYKHSNNKAM TTGAIAAMLS 120
TILYSRRFFP YYVYNIIEGL DEEGKGAVYS FDPVGSYQRD SFKAGGSASA MLQPLLDNQV 180
GFKNMQNVEH VPLTLDRAMR LVKDVFISAA ERDVYTGDAL RICIVTKEGI REETVPLRKD 240 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005839; C:proteasome core complex; ISS:UniProtKB.
 GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW.
 GO:0051603; P:proteolysis involved in cellular protein catabolic process; IEA:InterPro. 
Interpro
 IPR016050; Proteasome_bsu_CS.
 IPR001353; Proteasome_sua/b.
 IPR023333; Proteasome_suB-type. 
Pfam
 PF00227; Proteasome 
SMART
  
PROSITE
 PS00854; PROTEASOME_B_1
 PS51476; PROTEASOME_B_2 
PRINTS