| Tag | Content |
|---|
| CPLM ID | CPLM-013178 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytoskeleton-associated protein 2 |
Protein Synonyms/Alias | |
Gene Name | Ckap2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 234 | STTAAATKFADAKPV | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53- dependent manner. |
Sequence Annotation | REGION 160 319 Association with alpha- and beta-tubulin.
MOD_RES 561 561 Phosphothreonine (By similarity).
MOD_RES 577 577 Phosphoserine (By similarity).
MOD_RES 579 579 Phosphothreonine (By similarity).
MOD_RES 584 584 Phosphoserine (By similarity). |
Keyword | Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 664 AA |
Protein Sequence | MAESRKRFLG RAARNPLPVT RDLQLPPTRR DQPAFREQRK QKLKEYLLIR KTVFPYKQEN 60
QISRDQKMIT SEDRVQEGKK VVKLKTEVAD KENIESTVEK NCIPLKAGEV TSSEIHNSKD 120
NVQAVQLLST RDDLPGQTVT LDPACHHKDN KKMQMTAEKP KQDSNVSKKR VLGYYHGQIV 180
QSKINSFRKL PSVKGESLTT TKKLPTTVSK AMKAQSEPAN TVSVKASTTA AATKFADAKP 240
VSTASKDTLV RPPIRSLHSS SHGAAKQGLS RPLANVTVRK GMLDKESHRS EPVVSVVKAG 300
SSQAPSRSIA SKDAARTDSS NTRLMVKPKD TDQRRYTIAG ASVHRSAQLK DTTAERKAQM 360
TEWRTGKGKG LKRPPHSVVT QAEPKGQSEN PVGSFWTTMA EEDEQRLFTE KVNKTISECL 420
NLINEGCPKE EILATLNDLI HNIPDAKKLV KYWICLVRIE PITSPIENII SIYEKAILAG 480
AQPIEEMRHI IIDILTTKSQ EKVNLGENIE EAHATKEPIQ EVNADANVGS GKPGEENEHH 540
GKVEVYEDDQ DNKIKDPDLT TPDSKTEAGC IIRYNVSSTP RLQSMKKMQH DKNSTLKELK 600
FLTPVRRSRR IQDKTSRLPA MLKDHDPSVS SLEQLSELGG DAFVCRPNAA LCPLFFETDV 660
AEEE 664 |
Gene Ontology | GO:0005813; C:centrosome; IEA:Compara. GO:0005881; C:cytoplasmic microtubule; IDA:MGI. GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0000281; P:mitotic cytokinesis; IEA:Compara. GO:0007026; P:negative regulation of microtubule depolymerization; IDA:MGI. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |