CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039731
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Kelch repeat and BTB domain-containing protein 6 
Protein Synonyms/Alias
  
Gene Name
 KBTBD6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
112TNCTAILKFADAFGHubiquitination[1]
135SYIAQNFKQLSHMGSubiquitination[1]
197PSAAEVFKCVRWMHFubiquitination[1, 2]
218YLEGLLTKPIVKKYCubiquitination[1, 2, 3]
222LLTKPIVKKYCLDVIubiquitination[3]
223LTKPIVKKYCLDVIEubiquitination[2]
243RYGDLLYKSLVPVPNubiquitination[1, 2, 3, 4]
277QRLGMCAKEMVIFFGubiquitination[1]
302PYSGDLYKVPSPLTCubiquitination[1, 2]
343RTDLWVYKPAQNSWQubiquitination[1, 2, 3]
384RDPITGVKLKEVECYubiquitination[3]
386PITGVKLKEVECYNVubiquitination[2]
394EVECYNVKRNQWALVubiquitination[1, 2, 5]
469ICDIPVMKVYNPVRAubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kelch repeat; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 608 AA 
Protein Sequence
MQSREDAPRS RRLASPRGGK RPKKIHKPTV SAFFTGPEEL KDTASVTMHD VDAESFEVLV 60
DYCYTGRVSL SEANVERLYA ASDMLQLEYV REACASFLAR RLDLTNCTAI LKFADAFGHR 120
KLRSQAQSYI AQNFKQLSHM GSIREETLAD LTLAQLLAVL RLDSLDVESE QTVCHVAVQW 180
LEAAPKERGP SAAEVFKCVR WMHFTEEDQD YLEGLLTKPI VKKYCLDVIE GALQMRYGDL 240
LYKSLVPVPN SSSSSSSSNS LVSAAENPPQ RLGMCAKEMV IFFGHPRDPF LCCDPYSGDL 300
YKVPSPLTCL AHTRTVTTLA VCISPDHDIY LAAQPRTDLW VYKPAQNSWQ QLADRLLCRE 360
GMDVAYLNGY IYILGGRDPI TGVKLKEVEC YNVKRNQWAL VAPLPHSFLS FDLMVIRDYL 420
YALNSKRMFC YDPSHNMWLK CVSLKRNDFQ EACVFNEEIY CICDIPVMKV YNPVRAEWRQ 480
MNNIPLVSET NNYRIIKHGQ KLLLITSRTP QWKKNRVTVY EYDIRGDQWI NIGTTLGLLQ 540
FDSNFFCLSA RVYPSCLEPG QSFLTEEEEI PSESSTEWDL GGFSEPDSES GSSSSLSDDD 600
FWVRVAPQ 608 
Gene Ontology
  
Interpro
 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 
Pfam
 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 
SMART
 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 
PROSITE
 PS50097; BTB 
PRINTS