CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031249
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sodium/hydrogen exchanger 
Protein Synonyms/Alias
  
Gene Name
 SLC9A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
244FYHKMEMKQAIELVEubiquitination[1]
273SMQNIHPKSLPSERIubiquitination[1, 2]
399DLVNEELKGKVLGLSubiquitination[1]
411GLSRDPAKVAEEDEDubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Antiport; Complete proteome; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 476 AA 
Protein Sequence
MAYLSAELFH LSGIMALIAS GVVMRPYVEA NISHKSHTTI KYFLKMWSSV SETLIFIFLG 60
VSTVAGSHHW NWTFVISTLL FCLIARVLGV LGLTWFINKF RIVKLTPKDQ FIIAYGGLRG 120
AIAFSLGYLL DKKHFPMCDL FLTAIITVIF FTVFVQGMTI RPLVDLLAVK KKQETKRSIN 180
EEIHTQFLDH LLTGIEDICG HYGHHHWKDK LNRFNKKYVK KCLIAGERSK EPQLIAFYHK 240
MEMKQAIELV ESGGMGKIPS AVSTVSMQNI HPKSLPSERI LPALSKDKEE EIRKILRNNL 300
QKTRQRLRSY NRHTLVADPY EEAWNQMLLR RQKARQLEQK INNYLTVPAH KLDSPTMSRA 360
RIGSDPLAYE PKEDLPVITI DPASPQSPES VDLVNEELKG KVLGLSRDPA KVAEEDEDDD 420
GGIMMRSKET SSPGTDDVFT PAPSDSPSSQ RIQRCLSDPG PHPEPGEGEP FFPKGQ 476 
Gene Ontology
 GO:0016323; C:basolateral plasma membrane; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0015385; F:sodium:hydrogen antiporter activity; IEA:Compara.
 GO:0055007; P:cardiac muscle cell differentiation; IEA:Compara.
 GO:0016049; P:cell growth; IEA:Compara.
 GO:0070997; P:neuron death; IEA:Compara.
 GO:0045760; P:positive regulation of action potential; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0010740; P:positive regulation of intracellular protein kinase cascade; IEA:Compara.
 GO:0035794; P:positive regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0006885; P:regulation of pH; IEA:Compara.
 GO:0051930; P:regulation of sensory perception of pain; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara.
 GO:0001101; P:response to acid; IEA:Compara.
 GO:0010447; P:response to acidity; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara. 
Interpro
 IPR006153; Cation/H_exchanger.
 IPR018422; Cation/H_exchanger_CPA1.
 IPR001970; Na/H_exchanger_1.
 IPR004709; NaH_exchanger. 
Pfam
 PF00999; Na_H_Exchanger 
SMART
  
PROSITE
  
PRINTS
 PR01085; NAHEXCHNGR1.