CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025804
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock 70kDa protein 1A variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
124RLIGDAAKNQVALNPubiquitination[1]
139QNTVFDAKRLIGRKFubiquitination[1]
176PKVQVSYKGDTKAFYubiquitination[2]
227DSQRQATKDAGVIAGubiquitination[1]
314NHFVEEFKRKHKKDIubiquitination[1]
387STLEPVEKALRDAKLubiquitination[1]
416TRIPKVQKLLQDFFNubiquitination[1]
519EGERAMTKDNNLLGRubiquitination[1]
568KSTGKANKITITNDKubiquitination[1]
575KITITNDKGRLSKEEubiquitination[1]
592SMVQEAEKYKAEDEVubiquitination[1]
607QRERVSAKNALESYAubiquitination[1]
665DEFEHKRKELEQVCNubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Nucleotide-binding; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 709 AA 
Protein Sequence
LRSCCDSPLP FSRVTPVVPR LPRANLCGCR HRRVEFPASG RTELFSRIQC SVSSPQSQSR 60
ADREQGTGMA KAAAIGIDLG TTYSCVGVFQ HGKVEIIAND QGNRTTPSYV AFTDTERLIG 120
DAAKNQVALN PQNTVFDAKR LIGRKFGDPV VQSDMKHWPF QVINDGDKPK VQVSYKGDTK 180
AFYPEEISSM VLTKMKEIAE AYLGYPVTNA VITVPAYFND SQRQATKDAG VIAGLNVLRI 240
INEPTAAAIA YGLDRTGKGE RNVLIFDLGG GTFDVSILTI DDGIFEVKAT AGDTHLGGED 300
FDNRLVNHFV EEFKRKHKKD ISQNKRAVRR LRTACERAKR TLSSSTQASL EIDSLFEGID 360
FYTSITRARF EELCSDLFRS TLEPVEKALR DAKLDKAQIH DLVLVGGSTR IPKVQKLLQD 420
FFNGRDLNKS INPDEAVAYG AAVQAAILMG DKSENVQDLL LLDVAPLSLG LETAGGVMTA 480
LIKRNSTIPT KQTQIFTTYS DNQPGVLIQV YEGERAMTKD NNLLGRFELS GIPPAPRGVP 540
QIEVTFDIDA NGILNVTATD KSTGKANKIT ITNDKGRLSK EEIESMVQEA EKYKAEDEVQ 600
RERVSAKNAL ESYAFNMKSA VEDEGLKGKI SEADKKKVLD KCQEVISWLD ANTLAEKDEF 660
EHKRKELEQV CNPIISGLYQ GAGGPGPGGF GAQGPKGGSG SGPTIEEVD 709 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR018181; Heat_shock_70_CS.
 IPR013126; Hsp_70_fam. 
Pfam
 PF00012; HSP70 
SMART
  
PROSITE
 PS00297; HSP70_1
 PS00329; HSP70_2
 PS01036; HSP70_3 
PRINTS
 PR00301; HEATSHOCK70.