CPLM-014340

Genbank Nucleotide ID

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Protein Synonyms/Alias

60 kDa BRG-1/Brm-associated factor subunit A; BRG1-associated factor 60A; BAF60A; Protein D15KZ1; SWI/SNF complex 60 kDa subunit

Mus musculus (Mouse)

Position	Peptide	Type	References
223	LEDAALSKYDATKQK	acetylation	[1]
464	QSQCRDLKTMTDVVG	ubiquitination	[2]

[1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Involved in chromatin remodeling. Has a strong influence on the Vitamin D-mediated transcriptional activity from an enhancer Vitamin D receptor element (VDRE). May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand- bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

DOMAIN 291 390 SWIB.
REGION 43 167 Interaction with ESR1, NR1H4, NR3C1, PGR
REGION 168 474 Interaction with SMARCC1 and SMARCC2 (By
REGION 180 515 Necessary for GR/NR3C1-mediated

3D-structure; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; Direct protein sequencing; Neurogenesis; Nucleus; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0071565; C:nBAF complex; IDA:UniProtKB.
GO:0071564; C:npBAF complex; IDA:UniProtKB.
GO:0016514; C:SWI/SNF complex; IEA:Compara.
GO:0048096; P:chromatin-mediated maintenance of transcription; IEA:Compara.
GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO:0006337; P:nucleosome disassembly; IEA:Compara.

IPR019835; SWIB_domain.
IPR003121; SWIB_MDM2_domain.