| Tag | Content |
|---|
| CPLM ID | CPLM-024661 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 5 |
Protein Synonyms/Alias | Lens rupture protein 2; Rupture of lens cataract protein |
Gene Name | Dock5 |
Gene Synonyms/Alias | Lr2; Rlc |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1331 | LAETYESKVFDYEGL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. |
Sequence Annotation | DOMAIN 8 69 SH3.
DOMAIN 443 627 DHR-1.
DOMAIN 1231 1642 DHR-2.
MOD_RES 365 365 Phosphoserine (By similarity).
MOD_RES 818 818 N6-acetyllysine (By similarity).
MOD_RES 1765 1765 Phosphoserine (By similarity).
MOD_RES 1788 1788 Phosphoserine (By similarity).
MOD_RES 1793 1793 Phosphothreonine (By similarity).
MOD_RES 1832 1832 Phosphoserine (By similarity).
MOD_RES 1867 1867 Phosphoserine (By similarity). |
Keyword | Acetylation; Cataract; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1868 AA |
Protein Sequence | MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYAL QNRSKKGIFP 60
ETYIHLKEAT VEDGGQHETV IPGELPLVQE LTNTLREWAV IWRKLYVNNK VTLFRQLQQM 120
TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA KIDHGNRMLG LDLVVRDDNG NILDPDETST 180
VALFRAHEVA SKRIEEKIQE EKSILQNLDL RGQAIFSTVH TYGLYVNFKN FVCNIGEDAE 240
LFIALYDPDQ STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSTDLI RPRISLVCQI 300
VRVGRMELKE GKKHTCGLRR PFGVAVMDIS DIVHGKVDDE EKQHFIPFQQ IAMETYIRQR 360
QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW VSLKLLPGDL TQVQKNFSHL 420
VDRSTAIARK MGFPEIILPG DVRNDIYVTL IHGEFDKGKK KTPKNVEVTM SVFDEEGNLL 480
EKAIHPGAGY EGVSEYKSVV YYQVKQPCWY ETVKVFIAIE EVTRCHIRFT FRHRSSQESR 540
DKSERAFGVA FVKLMNADGT TLQDGRHDLV VYKGDNKKME DAKYYLTLPG TKAELEEKEL 600
QASKNPSVFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI KHNLKKLMEV 660
DGGEIVKFLQ DTLDALFNIM MEMSDNETYD FLVFDALVFI ISLIGDIKFQ HFNPVLETYI 720
YKHFSATLAH VKLSKVLNFY VANAEDPSKT ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ 780
SEDGDEFNDS IRQLFLAFNT LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPMELSVLF 840
CKFIQSIPDN QLVRQKLNCM TKIVESSLFQ QAECREVLLP LLTDQLSGQL DDHSTKPDHE 900
ASSQLLSNIL EVLDRTDVGP TSAHVQLIME RLLRRINRTV IGMSRQSPHI GSFVACMIAV 960
LRQMEDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN VYAKDWMVMN MTQNRVFLRA 1020
INQFAEVLTK SFMDQASFEL QLWNNYFHLA VAFLTHESLQ LETFSEAKRN KIVKKYGDMR 1080
KEIGFRIRDM WYNLGPHKIK FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNLSG 1140
NGNFHMFENE LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLANSG EAFAFLVSSL 1200
LENLLDYRTI IIHDESKENR MSCTVNVLNF YKDKKREDIY IRYLYKLRDL HRDCENYTEA 1260
AYTLLLHAEL LQWSDKPCVP HLLQRDSYYV YTQQELKEKL YQEIISYFDK GKMWEKAIKL 1320
SKELAETYES KVFDYEGLGS LLKKRALFYE NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI 1380
FIYRGKEYER REDFSLRLLT QFPNAEKMTS TTPPGEDIKS SPKQYLQCFT VKPVMSLPPS 1440
YKDKPVPEQI LNYYRANEVQ QFSYSRPFRK GEKDPENEFA TMWIERTTYR TAYTFPGILK 1500
WFEAKEISVE EISPLENAIE TMELTNERVS NCVQQHAWDH SLSVHPLSML LSGIVDPAVM 1560
GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQIPLL TEGIRIHGEK LTEQLKPLHA 1620
RLSSCFRELK EKVEKLYGVI TLPPSMTERK PSRAGSMVLP YILSSTLRRL SVTSVASSVI 1680
STSSNSSDNA SSRPGSDGSI LEPLFERRAS SGARVEDLPP KEDSENRISK FKRKDWNLSK 1740
SQVIAEKAPE PDVMSPGKKT QRPKSLQLVD SRLTPFHSPS PLQSTALSPP PLTPKATRTL 1800
SSPSLQTDGL TASVPPPPPP KSKPYESSQR NSAEIAPPLP VRRDSKAPPP PPPKARKSGI 1860
LSSEPGSQ 1868 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |