CPLM-000921

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-000921

UniProt Accession

KIF1B_HUMAN; O60333; A6NFS8; A6NKQ4; Q4VXC3; Q4VXC4; Q4VXC5; Q4VXC6; Q96Q94; Q9BV80; Q9P280

Genbank Protein ID

AX039604; AB017133; AF257176; AY043362; AB088210; AY139835; AB011163; AB040881; AL139424; AL358013; AL139424; AL358013; AL358013; AL139424; AL358013; AL139424; AL358013; AL139424; AL358013; AL139424; AL358013; BC001415; BC115395; BT007174; AK022977

Genbank Nucleotide ID

CAC16629.1; BAB69038.1; AAK49332.1; AAK85155.1; BAE02543.1; AAN17742.1; BAA25517.2; BAA95972.2; CAI95752.1; CAI95752.1; CAI95753.1; CAI95753.1; CAI95219.1; CAI95219.1; CAI95220.1; CAI95220.1; CAI95221.1; CAI95221.1; CAI95222.1; CAI95754.1; CAI95754.1; AAH01415.1; AAI15396.1; AAP35838.1; BAB14341.1

Protein Name

Kinesin-like protein KIF1B

Protein Synonyms/Alias

Klp

Gene Name

KIF1B

Gene Synonyms/Alias

KIAA0591; KIAA1448

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
930	RQEQIRFKNLQQQEI	ubiquitination	[1, 2]
939	LQQQEITKQLRRQNV	ubiquitination	[1, 2, 3]

Reference

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]

Functional Description

Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.

Sequence Annotation

DOMAIN 1 361 Kinesin-motor.
DOMAIN 556 612 FHA.
DOMAIN 1702 1799 PH.
NP_BIND 97 104 ATP (By similarity).
REGION 270 350 Interaction with KBP.
MOD_RES 1057 1057 Phosphoserine.
MOD_RES 1075 1075 Phosphothreonine.
MOD_RES 1454 1454 Phosphoserine.
MOD_RES 1487 1487 Phosphoserine.
MOD_RES 1610 1610 Phosphoserine.
MOD_RES 1613 1613 Phosphoserine.

Keyword

3D-structure; Alternative splicing; Apoptosis; ATP-binding; Charcot-Marie-Tooth disease; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Disease mutation; Microtubule; Mitochondrion; Motor protein; Neuropathy; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1816 AA

Protein Sequence

MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT 60
SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP 120
QLCEELFEKI NDNCNEEMSY SVEVSYMEIY CERVRDLLNP KNKGNLRVRE HPLLGPYVED 180
LSKLAVTSYT DIADLMDAGN KARTVAATNM NETSSRSHAV FTIVFTQKKH DNETNLSTEK 240
VSKISLVDLA GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVSK KKKKTDFIPY 300
RDSVLTWLLR ENLGGNSRTA MVAALSPADI NYDETLSTLR YADRAKQIKC NAVINEDPNA 360
KLVRELKEEV TRLKDLLRAQ GLGDIIDTSM GSLTSSPSSC SLSSQVGLTS VTSIQERIMS 420
TPGGEEAIER LKESEKIIAE LNETWEEKLR KTEAIRMERE ALLAEMGVAI REDGGTLGVF 480
SPKKTPHLVN LNEDPLMSEC LLYYIKDGIT RVGQADAERR QDIVLSGAHI KEEHCIFRSE 540
RSNSGEVIVT LEPCERSETY VNGKRVSQPV QLRSGNRIIM GKNHVFRFNH PEQARAEREK 600
TPSAETPSEP VDWTFAQREL LEKQGIDMKQ EMEKRLQEME ILYKKEKEEA DLLLEQQRLD 660
ADSDSGDDSD KRSCEESWKL ITSLREKLPP SKLQTIVKKC GLPSSGKKRE PIKMYQIPQR 720
RRLSKDSKWV TISDLKIQAV KEICYEVALN DFRHSRQEIE ALAIVKMKEL CAMYGKKDPN 780
ERDSWRAVAR DVWDTVGVGD EKIEDVMATG KGSTDVDDLK VHIDKLEDIL QEVKKQNNMK 840
DEEIKVLRNK MLKMEKVLPL IGSQEQKSPG SHKAKEPVGA GVSSTSENNV SKGDNGELAK 900
EERVSQLMNG DPAFRRGRLR WMRQEQIRFK NLQQQEITKQ LRRQNVPHRF IPPENRKPRF 960
PFKSNPKHRN SWSPGTHIII TEDEVIELRI PKDDEARKGN KEESQEKGGK GAFKDPQFPW 1020
GSQGMRSQDH IQVSKQHINN QQQPPQLRWR SNSLNNGQPK STRCQASASA ESLNSHSGHP 1080
TADVQTFQAK RHIHQHRQSY CNYNTGGQLE GNAATSYQKQ TDKPSHCSQF VTPPRMRRQF 1140
SAPNLKAGRE TTV 1153

Gene Ontology

GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO:0005875; C:microtubule associated complex; ISS:UniProtKB.
GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0043005; C:neuron projection; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016887; F:ATPase activity; ISS:UniProtKB.
GO:0019894; F:kinesin binding; TAS:UniProtKB.
GO:0003777; F:microtubule motor activity; ISS:UniProtKB.
GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO:0047497; P:mitochondrion transport along microtubule; IEA:Compara.
GO:0007274; P:neuromuscular synaptic transmission; ISS:UniProtKB.
GO:0007270; P:neuron-neuron synaptic transmission; ISS:UniProtKB.

Interpro

IPR000253; FHA_dom.
IPR022140; KIF1B.
IPR022164; Kinesin-like.
IPR019821; Kinesin_motor_CS.
IPR001752; Kinesin_motor_dom.
IPR027417; P-loop_NTPase.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR008984; SMAD_FHA_domain.

Pfam

PF12473; DUF3694
PF00498; FHA
PF12423; KIF1B
PF00225; Kinesin
PF00169; PH

SMART

SM00240; FHA
SM00129; KISc
SM00233; PH

PROSITE

PS50006; FHA_DOMAIN
PS00411; KINESIN_MOTOR_DOMAIN1
PS50067; KINESIN_MOTOR_DOMAIN2
PS50003; PH_DOMAIN

PRINTS

PR00380; KINESINHEAVY.