CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016372
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RUN and SH3 domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 Rusc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
641AARNLVQKAQLGDSRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. 
Sequence Annotation
 DOMAIN 515 659 RUN.
 DOMAIN 835 893 SH3.
 REGION 463 598 Interaction with TRAF6 (By similarity).
 REGION 599 665 Interaction with IKBKG (By similarity).  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Endosome; Golgi apparatus; Membrane; Microtubule; Nucleus; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; SH3 domain; Synapse; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 893 AA 
Protein Sequence
MLSPQRALLC NLNHIHLQHV SLGLHLSRRP ELREGPLSTP PPPGDTGGKE SRGPCSGTLV 60
DANSNSPAVP CRCCQEHGSS IENQQDPSQE EEAVSPSDPG CSSSLSSCSD LSPDESPVSV 120
YSRDLPGNED ANPQPSTLEL GSPLAPAGPS TCSPDSFCCS PDSCSGISSP PGPDLDSNCN 180
ALTTCQDLPS PGLEEEEDSG EQDLATSELS ETEDGRIDAG KAEPSWKINP IWKIDTEKTE 240
AGWKTIEDSD SGRKTDENTN SSLKTESGKL ASCLNTNSGS KIDAGKTDGG WRGDVSQEPV 300
PHRTITSFHE LAQKRKRGPG LPLVPQAKKD RSDWLIVFSP DTELPPTGSL GGSLAPPREV 360
TTFKELRSRS RAQPPPVPPR DPPAGWALVP PRPPPPPVPP RRKKNRLGLQ PIAEGLSEEG 420
RAASPRAGEE ASASQEPEEP RAHAVAGPSL FPRPPVFRFS ADGRPLLEGG GAGAPGSLLF 480
TPLTGWSNSR LRLLGAASPP EEQLLPVRLS PVGAYSPPTR GALPCLASPE LALLLSPLFP 540
RSSTFPAAAP LPRQVPAPPL PTPPCPPTAP RWTRRPPPPP RQLRSSWSFA GVPGAQRLWM 600
AEAQSGTGQL QEQKKGLLIA VSASVDKIIS HFGAARNLVQ KAQLGDSRLS PDVGHLVLTT 660
LCPALHALVA DGLKPFRKDL ITGQRRSSPW SVVEASVKPG SCTHSMGSLY SQVSRLAPLS 720
SSRSRFHAFI LGLLNTKQLE LWFSSLQEDA GLLSLLYLPT GFFSLARGSC PSLATELLLL 780
LQPLSVLTFH LDLLFEHHHH LPVGLQQAPA PSCPPPALQQ TMQAVLHWGE RLAQSLRGTS 840
GESTTDSSTP SARPPAGSWW DQLTQASRVY ASGGTEGFPL LRWGPRRHGT TAEAAQEAPP 900
PTEQTTPGRS VWLGRLFGVP GCPSETESGA FKSRRPSSWL PPTVSVLALV KRGTPPETPP 960
EALVSSPGSV VQADRAVRAL CDHTAAGPDQ LSFQRGELLR VIATVDEDWL RCGRDGVEGL 1020
VPVGYTSLVL 1030 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB.
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0015630; C:microtubule cytoskeleton; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0003779; F:actin binding; IDA:UniProtKB.
 GO:0000209; P:protein polyubiquitination; ISS:UniProtKB. 
Interpro
 IPR004012; Run.
 IPR001452; SH3_domain. 
Pfam
 PF02759; RUN
 PF00018; SH3_1 
SMART
 SM00593; RUN
 SM00326; SH3 
PROSITE
 PS50826; RUN
 PS50002; SH3 
PRINTS