| Tag | Content |
|---|
| CPLM ID | CPLM-016451 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial |
Protein Synonyms/Alias | Phosphatidylglycerophosphate synthase 1; PGP synthase 1; Silencer-associated factor |
Gene Name | Pgs1 |
Gene Synonyms/Alias | Saf |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 550 | KMVTPLIKNFF**** | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin (By similarity). |
Sequence Annotation | DOMAIN 212 238 PLD phosphodiesterase 1.
DOMAIN 457 490 PLD phosphodiesterase 2.
NP_BIND 121 128 ATP (Potential).
ACT_SITE 217 217 Potential.
ACT_SITE 219 219 Potential.
ACT_SITE 224 224 Potential. |
Keyword | ATP-binding; Complete proteome; Lipid biosynthesis; Lipid metabolism; Mitochondrion; Nucleotide-binding; Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome; Repeat; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 553 AA |
Protein Sequence | MAAPAAGPVF WRRLLGLLPG RPGLAALLGR LSDRLGRSRE RRRRRSPWLL LAPLLSPTVP 60
QVTSPPCCLC PEGVHRFQWI RNLVPEFGVS SSHVRVLSSP AEFFELMKGQ IKIAKRRVVM 120
ASLYLGTGPL EQELVDCLES SLEKSLQAKF PSDLKVSILL DFTRGSRGRK NSRTMLLPLL 180
QRFPERVRVS LFHTPNLRGL LRLLIPERFN ETIGLQHIKV YLFDNNVILS GANLSDSYFT 240
NRQDRYVFLQ DCAEIADFFT ELVDAVGDVS LQLQGDDTVE VVDGMVHPYK GDRAAYCRAA 300
NKRVMDVIHS ARARQQMLHA QTFHSDSLLS QEEAAAAGDR RPAPDTWIYP LIQMKPFEIQ 360
IDEIVTETLL TEAERGAKVF LTTGYFNLTQ AYMDLVLGTR AEYQILLASP EVNGFFGAKG 420
VAGAIPAAYV HIERQFYSEV CSLGQQDRVQ LQEYWRRGWT FHAKGLWLYL AGSSLPCLTL 480
IGSPNFGYRS VHRDLEAQIA IVTESRSLQQ QLHQEQEQLY LRSGVVTSAT FEQPGRQVKL 540
WVKMVTPLIK NFF 553 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:Compara. GO:0005739; C:mitochondrion; ISS:HGNC. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0008444; F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity; ISS:HGNC. GO:0032049; P:cardiolipin biosynthetic process; ISS:BHF-UCL. GO:0046339; P:diacylglycerol metabolic process; ISS:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |