CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028562
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone-lysine N-methyltransferase EHMT2 
Protein Synonyms/Alias
  
Gene Name
 EHMT2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
691PGREALEKALVIQESubiquitination[1]
716RQLYLSVKQGELQKVubiquitination[1]
742FQSDQQSKRTPLHAAubiquitination[1]
804RGGCVYSKEEDGSTCubiquitination[1]
939ANPELRNKEGDTAWDubiquitination[1]
977NRAIRTEKIICRDVAubiquitination[1]
1104LQLYRTAKMGWGVRAubiquitination[1, 2, 3]
1221RFWDIKSKYFTCQCGubiquitination[1, 2]
1231TCQCGSEKCKHSAEAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Chromosome; Complete proteome; Methyltransferase; Nucleus; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1267 AA 
Protein Sequence
MRGLPRGRGL MRARGRGRAA PPGSRGRGRG GPHRGRGRPR SLLSLPRAQA SWTPQLSTGL 60
TSPPVPCLPS QGEAPAEMGA LLLEKETRGA TERVHGSLGD TPRSEETLPK ATPDSLEPAG 120
PSSPASVTVT VGDEGADTPV GATPLIGDES ENLEGDGDLR GGRILLGHAT KSFPSSPSKG 180
GSCPSRAKMS MTGAGKSPPS VQSLAMRLLS MPGAQGAAAA GSEPPPATTS PEGQPKVHRA 240
RKTMSKPGNG QPPVPEKRPP EIQHFRMSDD VHSLGKVTSD LAKRRKLNSG GGLSEELGSA 300
RRSGEVTLTK GDPGSLEEWE TVVGDDFSLY YDSYSVDERV DSDSKSEVEA LTEQLSEEEE 360
EEEEEEEEEE EEEEEEEEEE DEESGNQSDR SGSSGRRKAK KKWRKDSPWV KPSRKRRKRE 420
PPRAKEPRGV NGVGSSGPSE YMEVPLGSLE LPSEGTLSPN HAGVSNDTSS LETERGFEEL 480
PLCSCRMEAP KIDRISERAG HKCMATESVD GELSGCNAAI LKRETMRPSS RVALMVLCET 540
HRARMVKHHC CPGCGYFCTA GTFLECHPDF RVAHRFHKAC VSQLNGMVFC PHCGEDASEA 600
QEVTIPRGDG VTPPAGTAAP APPPLSQDVP GRADTSQPSA RMRGHGEPRR PPCDPLADTI 660
DSSGPSLTLP NGGCLSAVGL PLGPGREALE KALVIQESER RKKLRFHPRQ LYLSVKQGEL 720
QKVILMLLDN LDPNFQSDQQ SKRTPLHAAA QKGSVEICHV LLQAGANINA VDKQQRTPLM 780
EAVVNNHLEV ARYMVQRGGC VYSKEEDGST CLHHAAKIGN LEMVSLLLST GQVDVNAQDS 840
GGWTPIIWAA EHKHIEVIRM LLTRGADVTL TDNEENICLH WASFTGSAAI AEVLLNARCD 900
LHAVNYHGDT PLHIAARESY HDCVLLFLSR GANPELRNKE GDTAWDLTPE RSDVWFALQL 960
NRKLRLGVGN RAIRTEKIIC RDVARGYENV PIPCVNGVDG EPCPEDYKYI SENCETSTMN 1020
IDRNITHLQH CTCVDDCSSS NCLCGQLSIR CWYDKDGRLL QEFNKIEPPL IFECNQACSC 1080
WRNCKNRVVQ SGIKVRLQLY RTAKMGWGVR ALQTIPQGTF ICEYVGELIS DAEADVREDD 1140
SYLFDLDNKD GEVYCIDARY YGNISRFINH LCDPNIIPVR VFMLHQDLRF PRIAFFSSRD 1200
IRTGEELGFD YGDRFWDIKS KYFTCQCGSE KCKHSAEAIA LEQSRLARLD PHPELLPELG 1260
SLPPVNT 1267 
Gene Ontology
 GO:0005694; C:chromosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-KW.
 GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR003616; Post-SET_dom.
 IPR007728; Pre-SET_dom.
 IPR003606; Pre-SET_Zn-bd_sub.
 IPR001214; SET_dom. 
Pfam
 PF12796; Ank_2
 PF05033; Pre-SET
 PF00856; SET 
SMART
 SM00248; ANK
 SM00508; PostSET
 SM00468; PreSET
 SM00317; SET 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50867; PRE_SET
 PS50280; SET 
PRINTS
 PR01415; ANKYRIN.