| Tag | Content |
|---|
| CPLM ID | CPLM-014491 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cytoplasmic dynein 1 intermediate chain 1 |
Protein Synonyms/Alias | Cytoplasmic dynein intermediate chain 1; Dynein intermediate chain 1, cytosolic; DH IC-1 |
Gene Name | Dync1i1 |
Gene Synonyms/Alias | Dnci1; Dncic1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 150 | LNKLGVSKVTQVDFL | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150- glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores. |
Sequence Annotation | REPEAT 283 332 WD 1.
REPEAT 336 376 WD 2.
REPEAT 385 426 WD 3.
REPEAT 435 475 WD 4.
REPEAT 480 525 WD 5.
REPEAT 528 568 WD 6.
REPEAT 574 613 WD 7.
REGION 1 123 Interaction with DCTN1.
MOD_RES 633 633 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Centromere; Chromosome; Complete proteome; Cytoplasm; Cytoskeleton; Dynein; Kinetochore; Microtubule; Motor protein; Phosphoprotein; Reference proteome; Repeat; Transport; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 643 AA |
Protein Sequence | MSDKSDLKAE LERKKQRLAQ IREEKKRKEE ERKKKEADMQ QKKEPVPDDS DLDRKRRETE 60
ALLQSIGISP EPPLVQPLHF LTWDTCYFHY LVPTPMSPSS KSVSTPSEAG SQDDLGPLTR 120
TLQWDTDPSV LQLQSDSELG RRLNKLGVSK VTQVDFLPRE VVSYSKETQT PLATHQSEED 180
EEDEEMVEPK VGHDSELENQ DKKQETKEAP PRELTEEEKQ QILHSEEFLI FFDRTIRVIE 240
RALAEDSDIF FDYSGRELEE KDGDVQAGAN LSFNRQFYDE HWSKHRVVTC MDWSLQYPEL 300
MVASYSNNED APHEPDGVAL VWNMKFKKTT PEYVFHCQSS VMSVCFARFH PNLVVGGTYS 360
GQIVLWDNRS HRRTPVQRTP LSAAAHTHPV YCVNVVGTQN AHNLITVSTD GKMCSWSLDM 420
LSTPQESMEL VYNKSKPVAV TGMAFPTGDV NNFVVGSEEG TVYTACRHGS KAGIGEVFEG 480
HQGPVTGINC HMAVGPIDFS HLFVTSSFDW TVKLWTTKHN KPLYSFEDNA DYVYDVMWSP 540
VHPALFACVD GMGRLDLWNL NSDTEVPTAS VAIEGAYALN RVRWAQGGKE VAVGDSEGRI 600
WIYDVGELAV PHNDEWTRFA RTLVEIRANR ADSEEEGAVE LAA 643 |
Gene Ontology | GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell. GO:0005868; C:cytoplasmic dynein complex; ISS:UniProtKB. GO:0000776; C:kinetochore; ISS:UniProtKB. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0048471; C:perinuclear region of cytoplasm; IDA:HGNC. GO:0000922; C:spindle pole; ISS:UniProtKB. GO:0031982; C:vesicle; ISS:UniProtKB. GO:0008017; F:microtubule binding; IDA:HGNC. GO:0003777; F:microtubule motor activity; IDA:HGNC. GO:0047496; P:vesicle transport along microtubule; IDA:HGNC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |