CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008027
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Prospero homeobox protein 1 
Protein Synonyms/Alias
 Homeobox prospero-like protein PROX1; PROX-1 
Gene Name
 Prox1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
212RENKRKQKLPQQQQQubiquitination[1]
232VSARKEQKREERRQLsumoylation[2]
326EMAENKPKREGSNKEsumoylation[2]
353KHLAETLKQELNTAMsumoylation[2]
556GLSLSLIKSECGDLQsumoylation[2]
611KTYFSDVKFNRCITSubiquitination[1]
700FNAIIAGKDVDPSWKubiquitination[1]
716AIYKVICKLDSEVPEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification.
 Shan SF, Wang LF, Zhai JW, Qin Y, Ouyang HF, Kong YY, Liu J, Wang Y, Xie YH.
 FEBS Lett. 2008 Nov 12;582(27):3723-8. [PMID: 18948102] 
Functional Description
 May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons. 
Sequence Annotation
 DNA_BIND 573 635 Prospero-type homeobox.
 REGION 636 737 Prospero-like.
 MOD_RES 177 177 Phosphoserine.
 MOD_RES 179 179 Phosphoserine.
 MOD_RES 291 291 Phosphoserine.
 MOD_RES 511 511 Phosphoserine.
 MOD_RES 514 514 Phosphoserine.
 MOD_RES 650 650 Phosphothreonine.  
Keyword
 Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 737 AA 
Protein Sequence
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS EQDVEYSVVQ 60
HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN MNKNGGTEPS FQASGLSSTG 120
SEVHQEDICS NSSRDSPPEC LSPFGRPTMS QFDVDRLCDE HLRAKRARVE NIIRGMSHSP 180
SVALRGNENE REMAPQSVSP RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK 240
QQLEDMQKQL RQLQEKFYQV YDSTDSENDE DGDLSEDSMR SEILDARAQD SVGRSDNEMC 300
ELDPGQFIDR ARALIREQEM AENKPKREGS NKERDHGPNS LQPEGKHLAE TLKQELNTAM 360
SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH NFHTANQRLQ CFGDVIIPNP 420
LDTFGSVQMP SSTDQTEALP LVVRKNSSEQ SASGPATGGH HQPLHQSPLS ATAGFTTPSF 480
RHPFPLPLMA YPFQSPLGAP SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP 540
AHPPSTAEGL SLSLIKSECG DLQDMSDISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS 600
NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST EELSITRDCE 660
LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK DVDPSWKKAI YKVICKLDSE 720
VPEIFKSPNC LQELLHE 737 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara.
 GO:0060414; P:aorta smooth muscle tissue morphogenesis; IMP:BHF-UCL.
 GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
 GO:0001709; P:cell fate determination; IMP:MGI.
 GO:0021707; P:cerebellar granule cell differentiation; IMP:BHF-UCL.
 GO:0021542; P:dentate gyrus development; IMP:BHF-UCL.
 GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IEP:BHF-UCL.
 GO:0060214; P:endocardium formation; IMP:BHF-UCL.
 GO:0002194; P:hepatocyte cell migration; IMP:MGI.
 GO:0070365; P:hepatocyte differentiation; IEP:BHF-UCL.
 GO:0072574; P:hepatocyte proliferation; IMP:MGI.
 GO:0048839; P:inner ear development; IMP:MGI.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0070309; P:lens fiber cell morphogenesis; IMP:BHF-UCL.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0001946; P:lymphangiogenesis; IEA:Compara.
 GO:0060836; P:lymphatic endothelial cell differentiation; IMP:MGI.
 GO:0070858; P:negative regulation of bile acid biosynthetic process; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0045071; P:negative regulation of viral genome replication; IEA:Compara.
 GO:0097150; P:neuronal stem cell maintenance; IMP:BHF-UCL.
 GO:0046619; P:optic placode formation involved in camera-type eye formation; IEP:BHF-UCL.
 GO:0031016; P:pancreas development; IEA:Compara.
 GO:0045787; P:positive regulation of cell cycle; IMP:BHF-UCL.
 GO:1901978; P:positive regulation of cell cycle checkpoint; IMP:MGI.
 GO:0045737; P:positive regulation of cyclin-dependent protein kinase activity; IEA:Compara.
 GO:0010595; P:positive regulation of endothelial cell migration; IEA:Compara.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Compara.
 GO:2000979; P:positive regulation of forebrain neuron differentiation; IMP:BHF-UCL.
 GO:0060421; P:positive regulation of heart growth; IMP:BHF-UCL.
 GO:2000179; P:positive regulation of neural precursor cell proliferation; IMP:BHF-UCL.
 GO:0060298; P:positive regulation of sarcomere organization; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0060849; P:regulation of transcription involved in lymphatic endothelial cell fate commitment; IEA:Compara.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0030240; P:skeletal muscle thin filament assembly; IMP:BHF-UCL.
 GO:0048845; P:venous blood vessel morphogenesis; IMP:BHF-UCL.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL.
 GO:0055005; P:ventricular cardiac myofibril development; IMP:BHF-UCL.
 GO:0060412; P:ventricular septum morphogenesis; IMP:BHF-UCL. 
Interpro
 IPR023082; Homeo_prospero_dom.
 IPR009057; Homeodomain-like.
 IPR007738; Prox1. 
Pfam
 PF05044; Prox1 
SMART
  
PROSITE
  
PRINTS