UniProt Accession

 SOX10_HUMAN; P56693 

Genbank Protein ID

 AJ001183; CR456584; BT020029; AL031587; BC002824; BC007595 

Genbank Nucleotide ID

 CAA04576.1; CAG30470.1; AAV38832.1; CAB62982.1; AAH02824.1; AAH07595.1 

Protein Name

 Transcription factor SOX-10 

Protein Synonyms/Alias

  

Gene Name

 SOX10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
208	AAIQAHYKSAHLDHR	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity). 

Sequence Annotation

 DNA_BIND 104 172 HMG box.
 MOTIF 134 145 Nuclear export signal.
 MOD_RES 24 24 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Deafness; Disease mutation; DNA-binding; Hirschsprung disease; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Waardenburg syndrome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 466 AA 

Protein Sequence

Gene Ontology

 GO:0031315; C:extrinsic to mitochondrial outer membrane; IEA:Compara.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:Compara.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; TAS:ProtInc.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0048469; P:cell maturation; IEA:Compara.
 GO:0048589; P:developmental growth; IEA:Compara.
 GO:0048546; P:digestive tract morphogenesis; IEA:Compara.
 GO:0048484; P:enteric nervous system development; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0030318; P:melanocyte differentiation; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0001755; P:neural crest cell migration; IEA:Compara.
 GO:0048709; P:oligodendrocyte differentiation; IEA:Compara.
 GO:0007422; P:peripheral nervous system development; IEA:Compara.
 GO:0014015; P:positive regulation of gliogenesis; IEA:Compara.
 GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR009071; HMG_box_dom.
 IPR022151; Sox_N. 

Pfam

 PF00505; HMG_box
 PF12444; Sox_N 

SMART

 SM00398; HMG 

PROSITE

 PS50118; HMG_BOX_2 

PRINTS