UniProt Accession

 SPS2_MOUSE; P97364; Q3TGI4; Q80ZY9 

Genbank Protein ID

 U43285; AK149516; AK168722; AK168965; BC016508; BC028966; BC043334 

Genbank Nucleotide ID

 AAC53024.2; BAE28931.1; BAE40564.1; BAE40770.1; AAH16508.1; AAH28966.1; AAH43334.2 

Protein Name

 Selenide, water dikinase 2 

Protein Synonyms/Alias

 Selenium donor protein 2; Selenophosphate synthase 2 

Gene Name

 Sephs2 

Gene Synonyms/Alias

 Sps2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
200	KVTPLMIKGFRDAAE	ubiquitination	[1]
274	QWLDNPEKWNKIKMV	ubiquitination	[1]
279	PEKWNKIKMVVSREE	ubiquitination	[1]
337	QNLAKQQKNEVSFVI	ubiquitination	[1]
358	AKMAAISKASGRFGL	acetylation	[2]
358	AKMAAISKASGRFGL	succinylation	[2]
358	AKMAAISKASGRFGL	ubiquitination	[1]
394	ARFCSEIKSSKYGEG	ubiquitination	[1]
422	RTARIIDKPRVIEVL	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Synthesizes selenophosphate from selenide and ATP. 

Sequence Annotation

 NP_BIND 322 328 ATP (Potential).
 ACT_SITE 63 63 Potential.  

Keyword

 ATP-binding; Complete proteome; Direct protein sequencing; Kinase; Nucleotide-binding; Reference proteome; Selenium; Selenocysteine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 452 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004756; F:selenide, water dikinase activity; IEA:EC. 

Interpro

 IPR010918; AIR_synth_C_dom.
 IPR000728; AIR_synth_N_dom.
 IPR016188; PurM_N-like.
 IPR004536; SelD. 

Pfam

 PF00586; AIRS
 PF02769; AIRS_C 

SMART

  

PROSITE

  

PRINTS