UniProt Accession

 MCBR_ECOLI; P76114; P77347 

Genbank Protein ID

 U00096; AP009048 

Genbank Nucleotide ID

 AAC74532.2; BAA15082.1 

Protein Name

 HTH-type transcriptional regulator McbR 

Protein Synonyms/Alias

  

Gene Name

 mcbR 

Gene Synonyms/Alias

 yncC; b1450; JW1445 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
30	QLSIGALKPGARLIT	acetylation	[1]
125	KLQQAQEKGDMEQII	acetylation	[1]
193	HLLLAALKAKDKEGC	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy. 

Sequence Annotation

 DOMAIN 10 77 HTH gntR-type.
 DNA_BIND 37 56 H-T-H motif (Potential).  

Keyword

 Complete proteome; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 221 AA 

Protein Sequence

Gene Ontology

 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:EcoCyc.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR027376; FadR/GntR_C.
 IPR011711; GntR_C.
 IPR000524; Tscrpt_reg_HTH_GntR.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF07729; FCD
 PF00392; GntR 

SMART

 SM00895; FCD
 SM00345; HTH_GNTR 

PROSITE

 PS50949; HTH_GNTR 

PRINTS