| Tag | Content |
|---|
| CPLM ID | CPLM-018497 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone-lysine N-methyltransferase setd3 |
Protein Synonyms/Alias | Endothelial differentiation inhibitory protein D10; SET domain-containing protein 3 |
Gene Name | Setd3 |
Gene Synonyms/Alias | D12Ertd771e |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 115 | LRATRDIKAEELFLW | ubiquitination | [1] | | 211 | HDVFSQYKNTARQYA | ubiquitination | [1] | | 439 | DRASLLLKTYKTTIE | ubiquitination | [1] | | 453 | EEDKIVLKNPDLSVR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Histone methyltransferase that methylates 'Lys-36' of histone H3 (H3K36me). H3 'Lys-36' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). |
Sequence Annotation | DOMAIN 94 314 SET.
MOD_RES 14 14 Phosphothreonine. |
Keyword | Activator; Alternative splicing; Chromatin regulator; Complete proteome; Methyltransferase; Nucleus; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 594 AA |
Protein Sequence | MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY TQIRALVEKI 60
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF 120
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP 180
SEYDTPLYFE EEEVRCLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT 240
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL 300
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA 360
GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNAEFPVSW 420
DNEVKLWTFL EDRASLLLKT YKTTIEEDKI VLKNPDLSVR ATMAIKLRLG EKEILEKAVK 480
SAAVNREYYR KHMEERAPLP RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE 540
TVSKVKAAEN GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL 594 |
Gene Ontology | GO:0000790; C:nuclear chromatin; IDA:MGI. GO:0046975; F:histone methyltransferase activity (H3-K36 specific); ISS:UniProtKB. GO:0042800; F:histone methyltransferase activity (H3-K4 specific); IDA:MGI. GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB. GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB. GO:0018023; P:peptidyl-lysine trimethylation; ISS:UniProtKB. GO:0051149; P:positive regulation of muscle cell differentiation; IMP:MGI. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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