CPLM-009440

Genbank Nucleotide ID

Protein Synonyms/Alias

Calm; Cam; Cam1; Cam2; Camb; Cam3; Camc

Mus musculus (Mouse)

Position	Peptide	Type	References
14	EEQIAEFKEAFSLFD	acetylation	[1]
22	EAFSLFDKDGDGTIT	acetylation	[1, 2, 3, 4, 5]
22	EAFSLFDKDGDGTIT	ubiquitination	[6]
31	GDGTITTKELGTVMR	acetylation	[3]
31	GDGTITTKELGTVMR	ubiquitination	[6]
76	FLTMMARKMKDTDSE	ubiquitination	[6]
78	TMMARKMKDTDSEEE	acetylation	[1]
78	TMMARKMKDTDSEEE	ubiquitination	[6]
95	EAFRVFDKDGNGYIS	acetylation	[1, 3, 4, 5]
95	EAFRVFDKDGNGYIS	ubiquitination	[6]

[1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
[2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
Simon GM, Cheng J, Gordon JI.
Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
[3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
[4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
PLoS One. 2012;7(12):e50545. [PMID: 23236377]
[5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
[6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]

Functional Description

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity).

DOMAIN 8 43 EF-hand 1.
DOMAIN 44 79 EF-hand 2.
DOMAIN 81 116 EF-hand 3.
DOMAIN 117 149 EF-hand 4.
MOD_RES 2 2 N-acetylalanine.
MOD_RES 22 22 N6-acetyllysine; alternate (By
MOD_RES 45 45 Phosphothreonine; by CaMK4 (By
MOD_RES 95 95 N6-acetyllysine (By similarity).
MOD_RES 100 100 Phosphotyrosine.
MOD_RES 102 102 Phosphoserine (By similarity).
MOD_RES 116 116 N6,N6,N6-trimethyllysine (By similarity).
MOD_RES 139 139 Phosphotyrosine (By similarity).
CROSSLNK 22 22 Glycyl lysine isopeptide (Lys-Gly)

3D-structure; Acetylation; Calcium; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Isopeptide bond; Metal-binding; Methylation; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005813; C:centrosome; IEA:Compara.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0005876; C:spindle microtubule; IEA:Compara.
GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0032465; P:regulation of cytokinesis; IEA:Compara.
GO:0001975; P:response to amphetamine; IEA:Compara.
GO:0051592; P:response to calcium ion; IEA:Compara.
GO:0051412; P:response to corticosterone stimulus; IEA:Compara.

IPR011992; EF-hand-like_dom.
IPR018247; EF_Hand_1_Ca_BS.
IPR002048; EF_hand_dom.
IPR001125; Recoverin.

PS00018; EF_HAND_1
PS50222; EF_HAND_2