| Tag | Content |
|---|
| CPLM ID | CPLM-016327 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | HEAT repeat-containing protein 2 |
Protein Synonyms/Alias | |
Gene Name | HEATR2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 43 | PGLEADSKPGRRRAL | ubiquitination | [1] | | 655 | SYLETVTKDILAPNL | ubiquitination | [1] | | 730 | RIINTFLKTSGGMTD | ubiquitination | [1] | | 750 | RIYPELLKRLDDVSN | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | |
Sequence Annotation | REPEAT 71 109 HEAT 1.
REPEAT 202 240 HEAT 2.
REPEAT 241 278 HEAT 3.
REPEAT 280 318 HEAT 4.
REPEAT 354 376 HEAT 5.
REPEAT 377 414 HEAT 6.
REPEAT 599 638 HEAT 7.
REPEAT 696 734 HEAT 8.
REPEAT 738 776 HEAT 9.
REPEAT 784 822 HEAT 10.
MOD_RES 2 2 N-acetylalanine. |
Keyword | Acetylation; Alternative splicing; Ciliopathy; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Polymorphism; Primary ciliary dyskinesia; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 855 AA |
Protein Sequence | MAALGVAEAV AAPHPAEGAE TAEAVELSRA LSRLLPGLEA DSKPGRRRAL EALRRALEEP 60
GPAADPTAFQ GPWARLLLPR LLRCLSDPAE GCRALAVHLL DLGLRRAARP RDALPRLLPA 120
LAARLAGPVP ARRPPEACEE LRLALVQLLG LAVDLCGAAL APHLDDALRA LRCSLLDPFA 180
AVRRESCSCA AALAQATPDH FHMQSESLIG PLMQTISHQH WKVRVAAIEA TGAVIHFGNG 240
KSVDDVLSHF AQRLFDDVPQ VRRAVASVVG GWLLCLRDRY SFFHKLIPLL LSSLNDEVPE 300
VRQLAASLWE DVGLQWQKEN EEDLKDKLDF APPTPPHYPP HERRPVLGCR ELVFRNLSKI 360
LPALCHDITD WVVGTRVKSA QLLPVLLLHA EDHATQHLEV VLRTLFQACT DEEAAVVQSC 420
TRSAELVGTF VSPEVFLKLI LSTLKKTPSA SGLLVLASAM RGCPREALQP HLAAIATELA 480
QAHICQASEN DLYLERLLLC VQALVSVCHE DCGVASLQLL DVLLTIVALA GATGLRDKAQ 540
ETMDSLAMVE GVSSCQDLYR KHIGPLLERV TASHLDWTAH SPELLQFSVI VAQSGPALGE 600
ALPHVVPTLR ACLQPSQDPQ MRLKLFSILS TVLLRATDTI NSQGQFPSYL ETVTKDILAP 660
NLQWHAGRTA AAIRTAAVSC LWALTSSEVL SAEQIRDVQE TLMPQVLTTL EEDSKMTRLI 720
SCRIINTFLK TSGGMTDPEK LIRIYPELLK RLDDVSNDVR MAAASTLVTW LQCVKGANAK 780
SYYQSSVQYL YRELLVHLDD PERAIQDAIL DVPGSPSPSA MIGSFLRPPH PWRTVSQLNL 840
FSS 843 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |