| Tag | Content |
|---|
| CPLM ID | CPLM-017037 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rho GTPase-activating protein 12 |
Protein Synonyms/Alias | Rho-type GTPase-activating protein 12 |
Gene Name | ARHGAP12 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 306 | TRDASISKGDFQNPG | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). |
Sequence Annotation | DOMAIN 12 74 SH3.
DOMAIN 265 298 WW 1.
DOMAIN 358 391 WW 2.
DOMAIN 463 575 PH.
DOMAIN 656 844 Rho-GAP.
MOD_RES 165 165 Phosphoserine.
MOD_RES 201 201 Phosphoserine.
MOD_RES 206 206 Phosphoserine (By similarity).
MOD_RES 213 213 Phosphoserine.
MOD_RES 215 215 Phosphoserine.
MOD_RES 231 231 Phosphothreonine (By similarity).
MOD_RES 240 240 Phosphoserine.
MOD_RES 243 243 Phosphotyrosine.
MOD_RES 521 521 Phosphothreonine (By similarity).
MOD_RES 592 592 Phosphoserine. |
Keyword | Alternative splicing; Complete proteome; GTPase activation; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 846 AA |
Protein Sequence | MKMADRSGKI IPGQVYIEVE YDYEYEAKDR KIVIKQGERY ILVKKTNDDW WQVKPDENSK 60
AFYVPAQYVK EVTRKALMPP VKQVAGLPNN STKIMQSLHL QRSTENVNKL PELSSFGKPS 120
SSVQGTGLIR DANQNFGPSY NQGQTVNLSL DLTHNNGKFN NDSHSPKVSS QNRTRSFGHF 180
PGPEFLDVEK TSFSQEQSCD SAGEGSERIH QDSESGDELS SSSTEQIRAT TPPNQGRPDS 240
PVYANLQELK ISQSALPPLP GSPAIQINGE WETHKDSSGR CYYYNRGTQE RTWKPPRWTR 300
DASISKGDFQ NPGDQELLSS EENYYSTSYS QSDSQCGSPP RGWSEELDER GHTLYTSDYT 360
NEKWLKHVDD QGRQYYYSAD GSRSEWELPK YNASSQQQRE IIKSRSLDRR LQEPIVLTKW 420
RHSTIVLDTN DKESPTASKP CFPENESSPS SPKHQDTASS PKDQEKYGLL NVTKIAENGK 480
KVRKNWLSSW AVLQGSSLLF TKTQGSSTSW FGSNQSKPEF TVDLKGATIE MASKDKSSKK 540
NVFELKTRQG TELLIQSDND TVINDWFKVL SSTINNQAVE TDEGIEEEIP DSPGIEKHDK 600
EKEQKDPKKL RSFKVSSIDS SEQKKTKKNL KKFLTRRPTL QAVREKGYIK DQVFGSNLAN 660
LCQRENGTVP KFVKLCIEHV EEHGLDIDGI YRVSGNLAVI QKLRFAVNHD EKLDLNDSKW 720
EDIHVITGAL KMFFRELPEP LFTFNHFNDF VNAIKQEPRQ RVAAVKDLIR QLPKPNQDTM 780
QILFRHLRRV IENGEKNRMT YQSIAIVFGP TLLKPEKETG NIAVHTVYQN QIVELILLEL 840
SSIFGR 846 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0043547; P:positive regulation of GTPase activity; IEA:GOC. GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome. GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |