CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014485
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Activity-regulated cytoskeleton-associated protein 
Protein Synonyms/Alias
 ARC/ARG3.1; Activity-regulated gene 3.1 protein; Arg3.1 
Gene Name
 Arc 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
24PRGGPAAKPNVILQIubiquitination[1]
252HMNGPAKKWWEFKQGubiquitination[1]
269KNWVEFKKEFLQYSEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors. 
Sequence Annotation
 REGION 89 100 Binds SH3GL1 or SH3GL3.
 REGION 195 214 Required for binding DNM2.  
Keyword
 Cell junction; Cell membrane; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Cytoskeleton; Developmental protein; Endocytosis; Endosome; Membrane; Postsynaptic cell membrane; Reference proteome; Synapse. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 396 AA 
Protein Sequence
MELDHMTTGG LHAYPAPRGG PAAKPNVILQ IGKCRAEMLE HVRRTHRHLL TEVSKQVERE 60
LKGLHRSVGK LENNLDGYVP TGDSQRWKKS IKACLCRCQE TIANLERWVK REMHVWREVF 120
YRLERWADRL ESMGGKYPVG SEPARHTVSV GVGGPEPYCQ EADGYDYTVS PYAITPPPAA 180
GELPEQESVG AQQYQSWVPG EDGQPSPGVD TQIFEDPREF LSHLEEYLRQ VGGSEEYWLS 240
QIQNHMNGPA KKWWEFKQGS VKNWVEFKKE FLQYSEGTLS REAIQRELDL PQKQGEPLDQ 300
FLWRKRDLYQ TLYVDAEEEE IIQYVVGTLQ PKFKRFLRHP LPKTLEQLIQ RGMEVQDGLE 360
QAAEPSVTPL PTEDETEALT PALTSESVAS DRTQPE 396 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
 GO:0015629; C:actin cytoskeleton; IDA:RGD.
 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005737; C:cytoplasm; TAS:RGD.
 GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0016477; P:cell migration; ISS:UniProtKB.
 GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0007492; P:endoderm development; IEA:Compara.
 GO:0007612; P:learning; IEP:RGD.
 GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
 GO:0048168; P:regulation of neuronal synaptic plasticity; IEP:RGD. 
Interpro
 IPR023263; Activity-reg_cytoskelet-assoc. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR02027; ARCARG31.