CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039182
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp34 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1664CKTYTMDKQPLNTGEubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 3155 AA 
Protein Sequence
LRYLCKLSDQ ELRQSAARNM ADLMWSTVKE PLDTTLCFDK ESLDLAFKYF MSPTLTMRLA 60
GLSQITNQLH TFNDVCNNES LVSDTETSIA KELADWLISN SVIEHIFGPN LHIEIIKQCQ 120
VILNFLAAEG RLSTQHIDCI WAAAQLKHCS RYIHDLFPSL IKNLDPVPLR HLLNLVSALE 180
PSVHTEQTLY LASMLIKALW NNALAAKAQL SKQSSFASLL NTNMPIGNKK EEEELRRAAP 240
SPWSPAASPQ SSDNSDTHQS GASDIEMDEQ LINRNKHVQQ RLSDTEESMQ GSSDETANSG 300
EDGSSGPGSS SGQSDGSSHE VNSSHASQSA GSPGSELQSE DIADIEALKE EEEGGAGKDL 360
VFNTEPLPSV DNRIRMLDAC AHSEDPEHDI SGEMSSAHIA QGSQESCITR SGDFLGETIG 420
NELFNCRQFI GPQHHHHHHH HHHHHHHHHH HHHHHHDGHM VDDMLSADDV SCSSSQVSAK 480
SEKNMADFDG EESGCEEELV QINSHAELTS HLQQHLPNLA SIYHEHLSQG PAVHKHQFSS 540
NAVTDINLDN VCKKGNTLLW DIVQDDDAIN LSEGLINEAE KLLCSLVCWF TDRQIRMRFI 600
EGCLENLGNN RSVVISLRLL PKLFGTFQQF GSSYDTHWIT MWAEKELNMM KLFFDNLVYY 660
IQGIREGRQK HTLYSHSAEV QVRLQFLTCV FSTLGSPDHF RLSLEQVDIL WHCLVEDSEC 720
YDDALHWFLN QVRSKDQHAM GMETYKHLFL EKMPQLKPET ISMTGLNLFQ HLCNLARLAT 780
SAYDGGSNSE LCGMDQFWGI ALRAQSGDVS RAAIQYINSY YINGKTGLEK EQEFISKCME 840
SLMIASSSLE QESHSSLTVI ERGLLMLKTH LEAFRRRFAY HLRQWQIEGT GISSHLKALS 900
DKQSLPLRVV CQPAGLPDKM TIEMYPSDQV ADLRAEVTHW YENLQKEQIN QQAQLQEFGQ 960
SSRKGEFPGG LMGPVRMISS GHELTTDYDE KALHELGFKD MQMVFVSLGA PRRERKGEGV 1020
QLPASCLPPP QKDNIPMLLL LQEPHLTTLF DLLEMLASFK PPSGKVAVDD SESLKCEELH 1080
LHAENLSRRV WELLMLLPTC PNMLTAFQSI SDEQSNDGVN WKELLKIKSA HKLLYALEII 1140
EALGKPNRRI RRESTGSYSD LYPDSDDSSE DQVENSKNSW TCKFVAAGGL QQLLEIFNSA 1200
MLEPKEHESW TVWQLDCLAC LLKLICQFAV DPSDLDLAYH DVFAWSGIAE SHRKRAWPGK 1260
SRKAAGDHAK SLHVPRLTEV FLVLVQGTSL IQRLMSVAYT YDHLAPRVLK AQSDHRSRHE 1320
VSHYSMWLLV SWAHCCSLVK SSLADSDHLQ DWLRKLTLLI PETAVRHESC NGLYKLSLSG 1380
LDGGDSIHRS FLLLAASTLL KFLPDAQALK PLRIDDYEEE PMLKPGCKEY FWLLCKLVDN 1440
IHIKDASQTT LLDLDALARH LADCIRSREI LDHLDGNLED DGLSGLLRLA TSVIKHKPPF 1500
KFSREGQEFL RDVFNLLFLL PSLKDRRQPK CKSHSSRAAA YDLLVEMVKG SVENYRLVHN 1560
WVMAQHMQSH APYKWDYWPH EDVRAECRFV GLTNLGATCY LASTIQQLYM IPEARQAVFT 1620
AKYSEDMKHK TTLLELQKMF TYLMESECKA YNPRPFCKTY TMDKQPLNTG EQKDMTEFFT 1680
DLITKVEEMS PELKNTVKSL FGGVITNNVV SLDCEHVSQT AEEFYTVRCQ VADMKNIYES 1740
LDEVTIKDTL EGDNMYTCSH CGKKVRAEKR ACFKKLPRIL SFNTMRYTFN MVTMMKEKVN 1800
THFSFPLRLD MTPYTEDFLM GKSDRKEGFK DVGDHSKDTE SYEYDLIGVT VHTGTADGGH 1860
YYSFIRDIVN PHAYKNNKWY LFNDAEVKPF DSAQLASECF GGEMTTKTYD SVTDKFMDFS 1920
FEKTHSAYML FYKRMEPEEE NGREYKFDVS SELLEWIWHD NMQFLQDKNI FEHTYFGFMW 1980
QLCSCIPSTL PDPKAVSLMT AKLSTSFVLE TFIHSKEKPT MLQWIELLTK QFNNSQAACE 2040
WFLDRMADDD WWPMQILIKC PNQIVRQMFQ RLCIHVIQRL RPVHAHLYLQ PGMEDGSDDM 2100
DASVEDIGGR SCVTRFVRTL LLIMEHGVKP HSKHLTEYFA FLYEFAKMGE EESQFLLSLQ 2160
AISTMVHFYM GTKGPENPQV EVLSEEEGEE EEEEEDILSL AEEKYRPAAL EKMIALVALL 2220
VEQSRSERHL TLSQTDMAAL TGGKGFPFLF QHIRDGINIR QTCNLIFSLC RYNNRLAEHI 2280
VSMLFTSIAK LTPEAANPFF KLLTMLMEFA GGPPGTPPFA SYILQRIWEV IEYNPSQCLD 2340
WLAVQTPRNK LAHSWVLQNM ENWVERFLLA HNYPRVRTSA AYLLVSLIPS NSFRQMFRST 2400
RSLHIPTRDL PLSPDTTVVL HQVYNVLLGL LSRAKLYVDA AVHGTTKLVP YLSFMTYCLI 2460
SKTEKLMFST YFMDLWNLFQ PKLSEPAIAT NHNKQALLSF WYNVCTECPE NIRLIVQNPV 2520
VTKNIAFNYI LADHDDQDVV LFNRGMLPAY YGILRLCCEQ SPAFTRQLAS HQNIQWAFKN 2580
LTPHASQYPG AVEELFNLMQ LFIAQRPDMR EEELEDIKQF KKTTISCYLR CLDGRSCWTT 2640
LISAFRILLE SDEDRLLVVF NRGLILMTES FNTLHMMYHE ATACHVTGDL AELLSIFLSV 2700
LKSTRPYLQR KDVKQALIQW QERIEFAHKL LTLLNSYSPP ELRNACIDVL KELVLLSPHD 2760
FLHTLVPFLQ HNHCTYHHSN IPSVLVAYEG LPLHLALFPK LWTELCQTQS AMSRNCVKLL 2820
CEDPVFAEYI KCILMDERTF LNNNIVYTFM THFLLKVQSQ VFSEANCASL ISTLITNLIN 2880
QYQNLQSDFT NRVEISKASA SLNGDLRALA LLLSVHTPKQ LNPALIPTLQ ELLNKCRTCL 2940
QQRNSLQEQE AKERKTKDDE GATPVKRRRV SSDEEHTVDS CIGDIKTDAR DVLTPTSTSD 3000
NETRDSSIID PGTEQDLPSP ENGSVKEYRM EGPSSFSEDG SHTRSQHAEE QSNSGRFDSC 3060
KDHSSKDATL ADDESEFPST SISAVLSDLA DLRSCDGQAL SSQDPEAAVS LSCGHSRGLI 3120
SHMQQHDILD TLCRTIESTI HVVTRISGKG NQAAS 3155 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS